FAM Cancer Research Results

FAM, Fatty Acid Metabolism: Click to Expand ⟱

Source:

Type:

Fatty Acid Metabolism - Fatty Acid Synthesis, Uptake, Transport, and Oxidation

Type: Metabolic pathway / lipid metabolism pathway

Function: Fatty acid metabolism encompasses the uptake, intracellular transport, de novo synthesis, elongation, desaturation, storage, mobilization, and mitochondrial or peroxisomal oxidation of fatty acids. Major regulatory components include SREBP-1/SREBF1, ACLY, ACACA/ACC, FASN, SCD, FABPs, CD36, ACSL enzymes, CPT1, and enzymes of mitochondrial β-oxidation. The pathway supplies membrane lipids, signaling molecules, ATP, reducing equivalents, and metabolic intermediates.

Cancer: ↑ / reprogrammed. Cancer cells frequently increase fatty-acid uptake, de novo lipogenesis, and/or fatty-acid oxidation to meet demands for membrane synthesis, energy production, redox homeostasis, survival, and signaling. Altered fatty-acid metabolism can promote proliferation, cancer stemness, invasion, metastasis, immune evasion, ferroptosis resistance, and treatment resistance. The dominant branch varies by tumor type and metabolic environment.

Alzheimer's Disease: ↕ Dysregulated. Alzheimer's disease is associated with altered fatty-acid composition, polyunsaturated fatty-acid metabolism, lipid transport, mitochondrial fatty-acid utilization, and membrane lipid homeostasis. These abnormalities can influence mitochondrial function, amyloid-β metabolism, tau pathology, neuroinflammation, synaptic function, and oxidative stress. Because individual fatty acids and metabolic branches may change in opposite directions, a single increase or decrease does not adequately describe the pathway.

Scientific Papers found: Click to Expand⟱

7757-

ISL,

Isoliquiritigenin Suppresses Oral Squamous Cell Carcinoma Progression by Targeting FABP5-Mediated Lipid Metabolism: Association with the circPOLB/miR-548ae-3p/C-MYC Axis

in-vitro,

Oral,

FABP5/E-FABP↓, FAM↓, TumCI↓, lipidLev↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

FABP5/E-FABP↓, 1, FAM↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

lipidLev↓, 1,

Migration(tgid=13) ⓘ

TumCI↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: FAM, Fatty Acid Metabolism

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells