miR-23a-3p Cancer Research Results

miR-23a-3p, MicroRNA-23a-3p: Click to Expand ⟱
Source:
Type:

miR-23a-3p - MicroRNA-23a-3p

Type: MicroRNA / post-transcriptional gene-expression regulator

Function: miR-23a-3p is a mature microRNA belonging to the miR-23/27/24 cluster. It regulates gene expression by binding target mRNAs and promoting transcript degradation or translational repression. It influences proliferation, apoptosis, epithelial-mesenchymal transition, migration, invasion, inflammation, and intracellular signaling pathways including PTEN/AKT and MAPK/ERK.

Cancer: ↑ Predominantly oncogenic in many cancer models. Increased miR-23a-3p can promote proliferation, survival, migration, invasion, epithelial-mesenchymal transition, metastasis, and treatment resistance by suppressing tumor-suppressive targets including PTEN, NDRG4, DUSP5, and RKIP/PEBP1. Tumor- and stromal-derived exosomal miR-23a-3p can also promote malignant signaling within the tumor microenvironment.
Scientific Papers found: Click to Expand⟱
7779- ISL,    Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury
- in-vivo, Alcohol, NA
*hepatoP↑, SL significantly reduced the liver-to-body weight ratios and biochemical index. The staining results showed that ISL remarkedly ameliorated the histopathological changes in the liver.
*FAM↑, ISL promoted fatty acid metabolism via induction in the expression of PGC-1α-target genes PPARα, CPT1α, and ACADs, and inhibited the ROS, TNF-α, IL-1β, and IL-6 expression.
*PGC-1α↑,
*PPARα↑,
*CPT1A↑,
*ACADS/SCAD↑,
*ROS↓,
*TNF-α↓,
*IL1β↓,
*IL6↓,
*miR-23a-3p↓, Significantly, the expression of miR-23a-3p was increased in the ALD, which was significantly decreased by ISL


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

ACADS/SCAD↑, 1,   FAM↑, 1,   miR-23a-3p↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CPT1A↑, 1,   PPARα↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL6↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: miR-23a-3p, MicroRNA-23a-3p
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1696  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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