CTSK Cancer Research Results

CTSK, Cathepsin K: Click to Expand ⟱
Source:
Type:

CTSK - Cathepsin K

Type: Lysosomal cysteine protease / collagenase

Function: Cathepsin K is a papain-family lysosomal cysteine protease with potent collagenolytic and elastolytic activity. It is highly expressed in osteoclasts and plays a major role in degradation of type I collagen and other extracellular-matrix proteins during bone resorption. CTSK also participates in extracellular-matrix remodeling, inflammatory signaling, epithelial-mesenchymal transition, and interactions between tumor cells and the bone microenvironment.

Cancer: ↑ Frequently increased or activated in cancer cells, osteoclasts, and cells of the tumor microenvironment. Elevated CTSK promotes extracellular-matrix degradation, tumor-cell migration and invasion, epithelial-mesenchymal transition, angiogenesis, osteolytic bone destruction, and establishment of bone metastases. CTSK inhibition can suppress invasion, bone resorption, and tumor progression in preclinical models.
Scientific Papers found: Click to Expand⟱
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, through different routes of administrations, including intravenously (IV), via hypodermic (IH) or intraperitoneal (IP) injection, and orally, have indicated that ISL exhibits a robust absorption capacity (absorption rate: ~60–90 min; oral absorptio
*BBB↓, ISL distribution mainly relies on the blood circulation, with the brain showing the lowest level of ISL due to the blood–brain barrier (BBB)
*BioAv↑, To improve solubility, enhancing its bioavailability and distribution, encapsulated ISL nanoparticles or nano-ISL have been developed.
selectivity↑, A selective cytotoxicity effect of ISL has been reported (Table 2 and Table 3), and the effective dose in tumor cell lines shows very little cytotoxic effect on normal cells.
*neuroP↑, Figure 4
*Inflam↓,
NF-kB↓,
TNF-α↓,
IL6↓,
IL1β↓,
IL10↓,
ICAM-1↓,
COX2/PTGS2↓,
PPARγ↑,
MMP2↓,
cFos↓,
VEGF↓,
CHOP/DDIT3↓,
CTSK↓,
CycB/CCNB1↑,
cycD1/CCND1↑,
TOP2↑,
PI3K↓, ISL also can inhibit the PI3K/AKT pathway and thus suppresses EMT and increases the antiproliferative effect
Akt↓,
mTOR↓,
MMP9↓,
TIMP1↓,
ChemoSen↑, ISL not only inhibits cancer cell growth by inducing apoptosis and autophagy, but can also enhance chemosensitivity
CSCs↓, ISL can interact synergistically with these first-line chemotherapy drugs through mediating cell death (apoptosis) and autophagy and suppressing breast CSCs


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CTSK↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↑, 1,   cycD1/CCND1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   CSCs↓, 1,   mTOR↓, 1,   PI3K↓, 1,   TOP2↑, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,   TIMP1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   ICAM-1↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 5

Scientific Paper Hit Count for: CTSK, Cathepsin K
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1697  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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