PSEN2/PS-2 Cancer Research Results

PSEN2/PS-2, Presenilin 2: Click to Expand ⟱
Source:
Type:

PSEN2 - Presenilin 2

Type: Intramembrane aspartyl protease / catalytic γ-secretase complex subunit

Function: PSEN2 is a catalytic component of the γ-secretase complex, together with nicastrin, APH1, and PEN2. The complex performs intramembrane proteolysis of multiple substrates including amyloid precursor protein (APP) and Notch receptors. γ-Secretase cleavage of APP generates amyloid-β peptides including Aβ40 and Aβ42. PSEN2 also participates in endolysosomal, calcium, mitochondrial, and cellular signaling functions.

Alzheimer's Disease: ↕ Altered function. Pathogenic PSEN2 mutations cause rare autosomal-dominant familial Alzheimer's disease by altering γ-secretase processing of APP. Many disease-associated mutations increase the relative production of aggregation-prone Aβ42, producing an increased Aβ42/Aβ40 ratio. The primary Alzheimer's mechanism therefore reflects altered PSEN2/γ-secretase activity rather than a consistent increase or decrease in PSEN2 expression.
Scientific Papers found: Click to Expand⟱
7839- AO,  ISQ,    The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model
- in-vivo, AD, NA - in-vivo, Obesity, NA
*Dose↝, For four weeks, 100 and 10 mg/kg/day of EAO and isoquercitrin, respectively, were administered orally
*Obesity↓, Administration of EAO and isoquercitrin significantly decreased body weight in HFD and Aβ-injected mice
*Leptin↓, decrease in leptin and an increase in adiponectin levels compared with the control group
*adiP↑,
*hepatoP↑, EAO- and isoquercitrin-administered groups attenuated liver damage
*PSEN1/PS1↓, administration of EAO and isoquercitrin groups down-regulated amyloidosis-related proteins in the brain such as β-secretase, presenilin (PS)-1 and PS-2 compared with HFD and Aβ-injected mice.
*PSEN2/PS-2↓,
*BACE/β-secretase↓,
*eff↑, EAO and isoquercitrin attenuated HFD and Aβ-induced obesity and amyloidosis, suggesting that they could be effective in preventing and treating both obesity and AD.

7801- IBC,    Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter
- in-vitro, CRC, HT-29
PSEN2/PS-2↓, The cytotoxic, MDR reversing, and ABCB1-inhibiting potency of isobavachalcone was studied in two cellular models:
AntiCan↑, active anticancer agent [8,9], inducing apoptosis and inhibiting the Akt and Erk signaling pathways [8,10]
Apoptosis↑,
Akt↓,
ERK↓,
*antiOx↑, Significant antioxidative properties of IBC [11,12] are likely to be responsible for its anti-inflammatory [13,14] and neuroprotective activities [15,16].
*Inflam↓,
*neuroP↑,
*toxicity↓, The analysis of the cytotoxic potential of IBC in human adenocarcinoma cell lines showed that the chalcone was virtually non-toxic to cancer cells in concentrations below 40 μM
selectivity↑,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

PSEN2/PS-2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Leptin↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,   neuroP↑, 1,   Obesity↓, 1,   toxicity↓, 1,  
Total Targets: 13

Scientific Paper Hit Count for: PSEN2/PS-2, Presenilin 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1699  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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