3-NT Cancer Research Results

3-NT, 3-Nitrotyrosine, Nitrotyrosine: Click to Expand ⟱
Source:
Type:

3-Nitrotyrosine - Nitrotyrosine

Abbreviation: 3-NT, 3-Nitrotyrosine, Nitrotyrosine

Type: Nitrosative stress biomarker / oxidatively modified amino acid

Function: 3-Nitrotyrosine is formed by nitration of tyrosine residues in proteins, primarily through reactive nitrogen species such as peroxynitrite. It is widely used as a biomarker of nitrosative stress, oxidative protein damage, and excessive nitric oxide/reactive oxygen species interactions. Protein tyrosine nitration can alter enzyme activity, protein structure, signaling, and cellular function.

Cancer: ↑ Frequently increased in tumors and tumor-associated inflammatory environments. Elevated nitrotyrosine reflects increased reactive oxygen and nitrogen species, peroxynitrite formation, inflammation, and oxidative protein damage and can accompany tumor progression, angiogenesis, immune dysfunction, and treatment-related oxidative stress.

Alzheimer's Disease: ↑ Increased 3-nitrotyrosine and protein tyrosine nitration are well-established indicators of oxidative and nitrosative stress in Alzheimer's disease. Elevated nitration affects proteins involved in energy metabolism, mitochondrial function, cytoskeletal regulation, and synaptic function and is associated with neuronal dysfunction and neurodegeneration.
Scientific Papers found: Click to Expand⟱
7830- SA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*cognitive↑, Studies showed that sinapic acid attenuated cognitive and memory impairments in Aβ- or STZinduced AD models mainly by the mechanisms of antioxidation and antineuroinflammation.
*memory↑,
*antiOx↑,
*NeuroI↓,
*iNOS↓, downregulating the expressions of nitrotyrosine and iNOS
*3-NT↓,
*Ach↑, sinapic acid also promoted the synthesis of ACh as evidenced by the upregulated ChAT expression in the hippocampus of sinapic acid-treated rats.
*ChAT↑,
*Dose↝, sinapic acid might play a critical role in the neuroprotective activity of mung bean, considering its relatively low effective dose (2.5−20 mg/kg) and high content in mung bean (0.15−230.48 mg/100 g).
*neuroP↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

3-NT↓, 1,   NeuroI↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ChAT↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: 3-NT, 3-Nitrotyrosine, Nitrotyrosine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1708  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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