AIF1/Iba-1 Cancer Research Results

AIF1/Iba-1, Allograft Inflammatory Factor 1 / Ionized Calcium-Binding Adapter Molecule 1: Click to Expand ⟱
Source:
Type:

AIF1 - Allograft Inflammatory Factor 1 / Ionized Calcium-Binding Adapter Molecule 1

Abbreviation: AIF1, Iba-1, IBA1

Type: Calcium-binding protein / microglial and macrophage activation marker

Function: AIF1, commonly called Iba-1, is a calcium-binding cytoplasmic protein expressed predominantly in microglia and macrophage-lineage cells. It participates in cytoskeletal remodeling, membrane ruffling, phagocytosis, migration, inflammatory signaling, and immune-cell activation. Iba-1 immunostaining is widely used to identify microglia and assess changes in microglial abundance and activation state.

Cancer: ↑ / immune-microenvironment associated. Increased AIF1/Iba-1 commonly reflects infiltration or activation of tumor-associated macrophages and other myeloid cells. Elevated AIF1-positive immune-cell populations can be associated with inflammation, angiogenesis, invasion, immunosuppression, and tumor progression, although interpretation depends strongly on macrophage phenotype and tumor type.

Alzheimer's Disease: ↑ Increased Iba-1 expression and immunoreactivity are commonly observed in Alzheimer's disease and experimental AD models and reflect increased microglial activation and/or accumulation around amyloid plaques and sites of neuronal injury. Reduced Iba-1 following treatment is generally interpreted as reduced microgliosis or neuroinflammation, although Iba-1 alone does not distinguish protective from detrimental microglial states.
Scientific Papers found: Click to Expand⟱
7852- isoO,    Neuroprotection of isoorientin against microglia activation induced by lipopolysaccharide via regulating GSK3β, NF-κb and Nrf2/HO-1 pathways
- in-vitro, AD, NA
*GSK‐3β↓, *TNF-α↓, *COX2/PTGS2↓, *BDNF↑, *AIF1/Iba-1↓, *IκB↑, *HO-1↑, *NF-kB↓, *NRF2↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AIF1/Iba-1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1,   NRF2↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IκB↑, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: AIF1/Iba-1, Allograft Inflammatory Factor 1 / Ionized Calcium-Binding Adapter Molecule 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1714  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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