ONOO Cancer Research Results

ONOO, Peroxynitrite: Click to Expand ⟱
Source:
Type:

Peroxynitrite - ONOO−

Abbreviation: ONOO−, Peroxynitrite

Type: Reactive nitrogen species / oxidant and nitrating species

Function: Peroxynitrite is a highly reactive nitrogen species formed primarily by the rapid reaction of nitric oxide with superoxide. It oxidizes and nitrates proteins, lipids, DNA, and mitochondrial components and can alter enzyme activity, membrane function, redox signaling, and cellular viability. Peroxynitrite is an important source of protein tyrosine nitration and formation of 3-nitrotyrosine.

Cancer: ↑ Frequently elevated in inflammatory and oxidative tumor microenvironments. Increased peroxynitrite can promote DNA damage, genomic instability, protein nitration, mitochondrial dysfunction, inflammatory signaling, immune suppression, and tumor progression. However, sufficiently high peroxynitrite levels can also induce cancer-cell death, making its effects concentration- and context-dependent.

Alzheimer's Disease: ↑ Increased peroxynitrite formation and nitrosative stress are associated with Alzheimer's disease. Elevated ONOO− contributes to protein nitration, mitochondrial dysfunction, lipid oxidation, DNA damage, synaptic impairment, and neuronal injury. Increased 3-nitrotyrosine in Alzheimer's disease is commonly used as indirect evidence of elevated peroxynitrite-mediated damage.
Scientific Papers found: Click to Expand⟱
7902- VT,    Vitexin Protects Against Scopolamine-Induced Cognitive Impairment by Preserving Synaptic Integrity and Modulating Nrf2/HO-1 and NF-κB Signaling Pathways
- in-vivo, AD, NA
*Dose↝, Sco (2 mg/kg/day, i.p.), Sco + vitexin (30 mg/kg/day, oral), Sco + donepezil (1.5 mg/kg/day, i.p.), vitexin alone, and donepezil alone
*Learn↑, co significantly impaired spatial learning and memory while increasing anxiety-like behaviors. Vitexin treatment markedly improved these deficits, with efficacy comparable to donepezil
*memory↑,
*AChE↓, Sco elevated acetylcholinesterase activity, lipid peroxidation, and oxidative/nitrosative stress markers (TOS, OSI, MDA, Peroxynitrite, NO, and NOS) while decreasing total antioxidant status (TAS). Vitexin reversed these changes.
*lipid-P↓,
*TOS↓,
*MDA↓,
*ONOO↓,
*NO↓,
*NOS2↓,
*TAC↑,
*BDNF↑, Sco reduced hippocampal BDNF, GDNF, PSD95, and synaptophysin levels and increased GFAP, IL-6, TNF-α, NF-κB p65, and COX-2 expression. Vitexin restored neurotrophic and synaptic proteins, suppressed astrocyte activation and inflammatory signaling, a
*GDNF↑,
*PSD95↑,
*GFAP↓,
*NF-kB↓,
*COX2/PTGS2↓,
*NRF2↑, and activated the Nrf2/HO-1 pathway.
*HO-1↑,
*neuroP↑, vitexin exerts significant neuroprotective and synaptoprotective effects against Sco-induced cognitive impairment by simultaneously restoring redox balance
*NeuroI↓, suppressing neuroinflammation, and preserving synaptic integrity.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

GDNF↑, 1,   GFAP↓, 1,   Learn↑, 1,   NeuroI↓, 1,   ONOO↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 1,   TAC↑, 1,   TOS↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   NF-kB↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   PSD95↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,   neuroP↑, 1,  
Total Targets: 21

Scientific Paper Hit Count for: ONOO, Peroxynitrite
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1717  State#:%  Dir#:1
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