IL1RL1/ST2 Cancer Research Results

IL1RL1/ST2, Interleukin-1 Receptor-Like 1 / ST2: Click to Expand ⟱

Source:

Type:

IL1RL1 - Interleukin-1 Receptor-Like 1 / ST2

Abbreviation: IL1RL1, ST2, ST2L

Type: Cytokine receptor / IL-33 receptor

Function: IL1RL1 encodes ST2, the principal receptor for IL-33. Membrane-bound ST2L forms a signaling receptor complex with IL1RAP and transduces IL-33-dependent inflammatory and immune signals. A soluble isoform, sST2, lacks the signaling domain and functions as a decoy receptor that binds extracellular IL-33 and limits IL-33/ST2L signaling.

Cancer: ↕ Context-dependent. ST2-mediated IL-33 signaling can support either tumor-promoting or antitumor immune responses depending on cancer type, immune-cell composition, receptor isoform, and tumor microenvironment.

Scientific Papers found: Click to Expand⟱

7928-

H2,

Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis

in-vivo,

Asthma,

 OVA sensitized asthma mouse model

*IL33↓, Serum and BALF levels of IL-33 and other alarmin and type II cytokines were greatly increased by OVA and inhibited by H2 in asthmatic mice.
*NF-kB↓, The expression of NF-κB (p65) and ST2 was upregulated by OVA and suppressed by H2.
*IL1RL1/ST2↓,
*ILC2↓, ILC2 population was markedly increased in OVA-induced asthmatic mice, and such increase was inhibited by H2.
*E-cadherin↑, E-cadherin and ZO-1 levels in airway tissues of asthmatic mice were significantly lower than that of control mice, and the reduction was recovered by H2 treatment.
*ZO-1↑,
*Inflam↓, These data demonstrated that H2 is efficient in suppressing allergen-induced asthma and could be developed as a therapeutics for asthma and other conditions of type II inflammation.

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

IL1RL1/ST2↓, 1, ILC2↓, 1,

Migration(tgid=13) ⓘ

E-cadherin↑, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL33↓, 1, Inflam↓, 1, NF-kB↓, 1,
Total Targets: 7

Scientific Paper Hit Count for: IL1RL1/ST2, Interleukin-1 Receptor-Like 1 / ST2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells