CXCL15 Cancer Research Results

CXCL15, C-X-C Motif Chemokine Ligand 15: Click to Expand ⟱
Source:
Type:

CXCL15 - C-X-C Motif Chemokine Ligand 15 / Lungkine

Abbreviation: CXCL15, Lungkine

Species: Mouse (Mus musculus)

Type: CXC chemokine / inflammatory signaling protein

Human Equivalent: No established direct human ortholog.

Function: CXCL15 is a mouse CXC chemokine expressed particularly strongly by lung epithelial cells. It is secreted into airway spaces and functions as a chemoattractant for neutrophils, contributing to pulmonary inflammatory responses, innate immune-cell recruitment, and lung-specific immune signaling.

Experimental Interpretation: ↑ CXCL15 generally indicates increased pulmonary chemokine signaling and neutrophil recruitment in mouse models. Because humans do not have a confirmed direct CXCL15 ortholog, results should not be assigned directly to a human CXCL15 target.
Scientific Papers found: Click to Expand⟱
7925- H2,    Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice
- in-vivo, Asthma, NA
*Dose?, received inhalation of 67% high concentration of hydrogen gas for 60 min once a day for 7 consecutive days after OVA or PBS challenge respectively
*IL4↓, Increased level of IL-4, IL-13, TNF-α and CXCL15 in the BALF and IL-4 in the serum were decreased significantly after inhalation.
*IL13↓,
*TNF-α↓,
*CXCL15↓,
*SOD↑, Hydrogen gas inhalation markedly upregulated the activity of decreased superoxide dismutase
*MDA↓, and significantly attenuated the increased level of malondialdehyde and myeloperoxidase
*MPO↓,
*ROS↓, Hydrogen gas inhalation improves lung function and protects established airway inflammation in the allergic asthmatic mice model which may be associated with the inhibition of oxidative stress process.
*antiOx↑, therapeutic effects of molecular hydrogen on various diseases have been investigated regarding its antioxidation capability [4] and its anti-inflammation [5] and anti-apoptosis
*Inflam↓,
*Apoptosis↓,
*toxicity↓, it is sufficiently mild that it does not disturb metabolic oxidation-reduction reactions or ROS-mediated cell signalling. Thus, it may be a safe and effective antioxidant for pulmonary diseases
*Stroke↓, , accumulating evidence has demonstrated various types of diseases involving oxidative stress, including ischaemic heart disease [7], stroke [8], acute lung injury [9] and inflammatory bowel disease
*Airway↓, Hydrogen gas inhalation decreased lung resistance in the asthmatic mice model
*Neut↓, There was a significant increase in the number of total cells, neutrophils , eosinophils , lymphocytes . Hydrogen gas inhalation resulted in significant reduction in the number of total cells
*Eos↓,
*BALF-Lym↓,
*BALF-Infl↓, Hydrogen gas inhalation attenuated the elevated levels of inflammatory cytokines present in BALF from the asthmatic mouse model
*AirwayM↓, In our study, we found the hydrogen gas inhalation significantly alleviated the pathologic inflammation degree and mucus content in the lung tissue.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Airway↓, 1,   AirwayM↓, 1,   BALF-Infl↓, 1,   BALF-Lym↓, 1,   CXCL15↓, 1,   Eos↓, 1,   IL13↓, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   MDA↓, 1,   MPO↓, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL4↓, 1,   Inflam↓, 1,   Neut↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 20

Scientific Paper Hit Count for: CXCL15, C-X-C Motif Chemokine Ligand 15
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1724  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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