Airway Cancer Research Results

Airway, Airway Resistance/Airway Resistance: Click to Expand ⟱
Source:
Type:

Airway Resistance

Aliases: Lung Resistance; Pulmonary Resistance; Raw; RL

Definition: Airway resistance is the opposition to airflow through the respiratory tract. It increases when airway diameter decreases because of bronchoconstriction, airway-wall swelling, mucus accumulation, or structural remodeling. Lung resistance or pulmonary resistance (RL) is commonly reported in animal asthma studies and may include resistance arising from both the conducting airways and other components of the respiratory system.

Asthma relevance: Airway/lung resistance is commonly increased in asthma and is frequently measured after challenge with methacholine or another bronchoconstrictor. A reduction in elevated or methacholine-induced resistance generally indicates improved airway function.

Direction:
Airway Resistance ↑ = generally adverse
Airway Resistance ↓ = generally beneficial in asthma

Typical pathway:
Bronchoconstriction / mucus / airway inflammation → airway lumen narrowing → Airway Resistance ↑



Scientific Papers found: Click to Expand⟱
7926- H2,    Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model
- in-vivo, Asthma, NA
*Dose↝, Hydrogen gas was delivered to the mice through inhalation twice a day (2 h once) for 7 consecutive days
*Airway↓, Hydrogen gas inhalation significantly alleviated OVA-induced airway hyperresponsiveness, inflammation and goblet cell hyperplasia, diminished TH2 response and decreased IL-4 as well as IgE levels, reduced malondialdehyde (MDA) production
*BALF-Infl↓,
*Th2↓,
*IL4↓,
*IgE↓,
*MDA↓,
*SOD↑, increased superoxide dismutase (SOD) activity
*NF-kB↓, hydrogen gas inhalation inhibited NF-κB activation and markedly activated Nrf2 pathway in OVA-induced asthmatic mice.
*NRF2↑,

7925- H2,    Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice
- in-vivo, Asthma, NA
*Dose?, received inhalation of 67% high concentration of hydrogen gas for 60 min once a day for 7 consecutive days after OVA or PBS challenge respectively
*IL4↓, Increased level of IL-4, IL-13, TNF-α and CXCL15 in the BALF and IL-4 in the serum were decreased significantly after inhalation.
*IL13↓,
*TNF-α↓,
*CXCL15↓,
*SOD↑, Hydrogen gas inhalation markedly upregulated the activity of decreased superoxide dismutase
*MDA↓, and significantly attenuated the increased level of malondialdehyde and myeloperoxidase
*MPO↓,
*ROS↓, Hydrogen gas inhalation improves lung function and protects established airway inflammation in the allergic asthmatic mice model which may be associated with the inhibition of oxidative stress process.
*antiOx↑, therapeutic effects of molecular hydrogen on various diseases have been investigated regarding its antioxidation capability [4] and its anti-inflammation [5] and anti-apoptosis
*Inflam↓,
*Apoptosis↓,
*toxicity↓, it is sufficiently mild that it does not disturb metabolic oxidation-reduction reactions or ROS-mediated cell signalling. Thus, it may be a safe and effective antioxidant for pulmonary diseases
*Stroke↓, , accumulating evidence has demonstrated various types of diseases involving oxidative stress, including ischaemic heart disease [7], stroke [8], acute lung injury [9] and inflammatory bowel disease
*Airway↓, Hydrogen gas inhalation decreased lung resistance in the asthmatic mice model
*Neut↓, There was a significant increase in the number of total cells, neutrophils , eosinophils , lymphocytes . Hydrogen gas inhalation resulted in significant reduction in the number of total cells
*Eos↓,
*BALF-Lym↓,
*BALF-Infl↓, Hydrogen gas inhalation attenuated the elevated levels of inflammatory cytokines present in BALF from the asthmatic mouse model
*AirwayM↓, In our study, we found the hydrogen gas inhalation significantly alleviated the pathologic inflammation degree and mucus content in the lung tissue.

7933- H2,    Hydrogen inhalation ameliorates lung inflammation in mice with asthma
- in-vivo, Asthma, NA
*antiOx↑, Hydrogen has been shown to exhibit antioxidant and anti-inflammatory properties that are beneficial for a range of diseases.
*Inflam↓,
*IL4↓, Hydrogen inhalation attenuated the immune response; decreased the levels of IL-4, IL-5 and IL-13;
*IL5↓,
*IL13↓,
*IL10↑, and further increased the mRNA expression levels of Treg-associated cytokines, namely, IL-10 and TGF-β1, thereby bolstering the body's inflammatory resistance mechanisms.
*TGF-β1↑,
*IgE↓, it also reduced total serum IgE levels and malondialdehyde (MDA) production and increased superoxide dismutase (SOD) secretion in lung tissue.
*MDA↓,
*SOD↑,
*Airway↓, Inhalation of hydrogen decreases airway resistance in asthmatic mice


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Airway↓, 3,   AirwayM↓, 1,   BALF-Infl↓, 2,   BALF-Lym↓, 1,   CXCL15↓, 1,   Eos↓, 1,   IgE↓, 2,   IL13↓, 2,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   MDA↓, 3,   MPO↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Migration(tgid=13) ⓘ

TGF-β1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL10↑, 1,   IL4↓, 3,   IL5↓, 1,   Inflam↓, 2,   Neut↓, 1,   NF-kB↓, 1,   Th2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,   Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 28

Scientific Paper Hit Count for: Airway, Airway Resistance/Airway Resistance
3 Hydrogen Gas
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1725  State#:%  Dir#:1
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