BALF-Infl Cancer Research Results

BALF-Infl, Total BALF Inflammatory Cells: Click to Expand ⟱
Source:
Type:

Total BALF Inflammatory Cells

Aliases: BALF Total Cells; Total BALF Cell Count; Bronchoalveolar Lavage Inflammatory Cells

Definition: The total number of inflammatory cells recovered from bronchoalveolar lavage fluid, typically including macrophages, eosinophils, neutrophils, and lymphocytes.

Asthma relevance: In experimental asthma, increased BALF inflammatory-cell counts reflect recruitment of immune cells into the lower airways. Total BALF cells and differential BALF cell counts are among the most common measures of airway inflammation in animal models.

Direction:
Total BALF Inflammatory Cells ↑ = generally adverse / increased airway inflammation
Total BALF Inflammatory Cells ↓ = generally beneficial



Scientific Papers found: Click to Expand⟱
7926- H2,    Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model
- in-vivo, Asthma, NA
*Dose↝, Hydrogen gas was delivered to the mice through inhalation twice a day (2 h once) for 7 consecutive days
*Airway↓, Hydrogen gas inhalation significantly alleviated OVA-induced airway hyperresponsiveness, inflammation and goblet cell hyperplasia, diminished TH2 response and decreased IL-4 as well as IgE levels, reduced malondialdehyde (MDA) production
*BALF-Infl↓,
*Th2↓,
*IL4↓,
*IgE↓,
*MDA↓,
*SOD↑, increased superoxide dismutase (SOD) activity
*NF-kB↓, hydrogen gas inhalation inhibited NF-κB activation and markedly activated Nrf2 pathway in OVA-induced asthmatic mice.
*NRF2↑,

7925- H2,    Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice
- in-vivo, Asthma, NA
*Dose?, received inhalation of 67% high concentration of hydrogen gas for 60 min once a day for 7 consecutive days after OVA or PBS challenge respectively
*IL4↓, Increased level of IL-4, IL-13, TNF-α and CXCL15 in the BALF and IL-4 in the serum were decreased significantly after inhalation.
*IL13↓,
*TNF-α↓,
*CXCL15↓,
*SOD↑, Hydrogen gas inhalation markedly upregulated the activity of decreased superoxide dismutase
*MDA↓, and significantly attenuated the increased level of malondialdehyde and myeloperoxidase
*MPO↓,
*ROS↓, Hydrogen gas inhalation improves lung function and protects established airway inflammation in the allergic asthmatic mice model which may be associated with the inhibition of oxidative stress process.
*antiOx↑, therapeutic effects of molecular hydrogen on various diseases have been investigated regarding its antioxidation capability [4] and its anti-inflammation [5] and anti-apoptosis
*Inflam↓,
*Apoptosis↓,
*toxicity↓, it is sufficiently mild that it does not disturb metabolic oxidation-reduction reactions or ROS-mediated cell signalling. Thus, it may be a safe and effective antioxidant for pulmonary diseases
*Stroke↓, , accumulating evidence has demonstrated various types of diseases involving oxidative stress, including ischaemic heart disease [7], stroke [8], acute lung injury [9] and inflammatory bowel disease
*Airway↓, Hydrogen gas inhalation decreased lung resistance in the asthmatic mice model
*Neut↓, There was a significant increase in the number of total cells, neutrophils , eosinophils , lymphocytes . Hydrogen gas inhalation resulted in significant reduction in the number of total cells
*Eos↓,
*BALF-Lym↓,
*BALF-Infl↓, Hydrogen gas inhalation attenuated the elevated levels of inflammatory cytokines present in BALF from the asthmatic mouse model
*AirwayM↓, In our study, we found the hydrogen gas inhalation significantly alleviated the pathologic inflammation degree and mucus content in the lung tissue.

7934- H2,    Hydrogen-generating silicon-based agent is effective in a mouse model of ovalbumin-induced allergic bronchial asthma
- in-vivo, Asthma, NA
*IgE↓, Silicon-based agent tended to decrease the total IgE concentration in serum
*antiOx↑, Hydrogen therapy, which involves the intake of hydrogen as an antioxidant, has been reported to be effective against various oxidative stress-related diseases.
*Eos↓, The administration in the diet of this Si-based agent to a model mouse of allergic bronchial asthma significantly suppressed eosinophil counts in the BALF and reduced inflammatory cell infiltration in the lungs
*BALF-Infl↓,
*IL5↓, the expressions of interleukins 5, and 13 and C–C motif chemokine 11 in lung tissue tended to decreased in the Si group compared with those in the control group
*IL13↓,
*CCL11↓,


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Airway↓, 2,   AirwayM↓, 1,   BALF-Infl↓, 3,   BALF-Lym↓, 1,   CCL11↓, 1,   CXCL15↓, 1,   Eos↓, 2,   IgE↓, 2,   IL13↓, 2,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   MDA↓, 2,   MPO↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL4↓, 2,   IL5↓, 1,   Inflam↓, 1,   Neut↓, 1,   NF-kB↓, 1,   Th2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,   Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 27

Scientific Paper Hit Count for: BALF-Infl, Total BALF Inflammatory Cells
3 Hydrogen Gas
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1732  State#:%  Dir#:1
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