Eos Cancer Research Results

Eos, Eosinophils: Click to Expand ⟱
Source:
Type:

Eosinophils

Definition: Eosinophils are granulocytic immune cells strongly involved in Type-2 and allergic airway inflammation. They release cytotoxic granule proteins, lipid mediators, cytokines, and reactive oxygen species that can contribute to epithelial injury and airway hyperresponsiveness.

Asthma relevance: Elevated eosinophils are characteristic of eosinophilic asthma and are commonly measured in blood, sputum, airway tissue, and bronchoalveolar lavage fluid (BALF). In experimental allergic asthma, BALF eosinophil counts are one of the most frequently reported inflammatory endpoints.

Direction:
Eosinophils ↑ = generally adverse in eosinophilic asthma
Eosinophils ↓ = generally beneficial

Common measurement contexts: BALF eosinophils; sputum eosinophils; blood eosinophils; airway tissue eosinophils

Typical pathway:
IL-5 ↑ + CCL11 / Eotaxin ↑ → eosinophil recruitment and survival ↑ → airway inflammation ↑



Scientific Papers found: Click to Expand⟱
7934- H2,    Hydrogen-generating silicon-based agent is effective in a mouse model of ovalbumin-induced allergic bronchial asthma
- in-vivo, Asthma, NA
*IgE↓, *antiOx↑, *Eos↓, *BALF-Infl↓, *IL5↓, *IL13↓, *CCL11↓,
7932- H2,    Hydrogen Gas Inhalation Alleviates Airway Inflammation and Oxidative Stress on Ovalbumin-Induced Asthmatic BALB/c Mouse Model
- in-vivo, Asthma, NA
*antiOx↑, *Inflam↓, *ROS↓, *TAC↑, *IgE↓, *Dose↝, *NLR↓, *IL4↓, *IL5↓, *IL13↓, *GM-CSF↓, *NO↓, *GPx↑, *Eos↓,
7925- H2,    Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice
- in-vivo, Asthma, NA
*Dose?, *IL4↓, *IL13↓, *TNF-α↓, *CXCL15↓, *SOD↑, *MDA↓, *MPO↓, *ROS↓, *antiOx↑, *Inflam↓, *Apoptosis↓, *toxicity↓, *Stroke↓, *Airway↓, *Neut↓, *Eos↓, *BALF-Lym↓, *BALF-Infl↓, *AirwayM↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Airway↓, 1,   AirwayM↓, 1,   BALF-Infl↓, 2,   BALF-Lym↓, 1,   CCL11↓, 1,   CXCL15↓, 1,   Eos↓, 3,   IgE↓, 2,   IL13↓, 3,   NLR↓, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   GPx↑, 1,   MDA↓, 1,   MPO↓, 1,   ROS↓, 2,   SOD↑, 1,   TAC↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

GM-CSF↓, 1,   IL4↓, 2,   IL5↓, 2,   Inflam↓, 2,   Neut↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,   Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 29

Scientific Paper Hit Count for: Eos, Eosinophils
3 Hydrogen Gas
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1734  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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