Eos Cancer Research Results

Eos, Eosinophils: Click to Expand ⟱
Source:
Type:

Eosinophils

Definition: Eosinophils are granulocytic immune cells strongly involved in Type-2 and allergic airway inflammation. They release cytotoxic granule proteins, lipid mediators, cytokines, and reactive oxygen species that can contribute to epithelial injury and airway hyperresponsiveness.

Asthma relevance: Elevated eosinophils are characteristic of eosinophilic asthma and are commonly measured in blood, sputum, airway tissue, and bronchoalveolar lavage fluid (BALF). In experimental allergic asthma, BALF eosinophil counts are one of the most frequently reported inflammatory endpoints.

Direction:
Eosinophils ↑ = generally adverse in eosinophilic asthma
Eosinophils ↓ = generally beneficial

Common measurement contexts: BALF eosinophils; sputum eosinophils; blood eosinophils; airway tissue eosinophils

Typical pathway:
IL-5 ↑ + CCL11 / Eotaxin ↑ → eosinophil recruitment and survival ↑ → airway inflammation ↑



Scientific Papers found: Click to Expand⟱
7925- H2,    Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice
- in-vivo, Asthma, NA
*Dose?, received inhalation of 67% high concentration of hydrogen gas for 60 min once a day for 7 consecutive days after OVA or PBS challenge respectively
*IL4↓, Increased level of IL-4, IL-13, TNF-α and CXCL15 in the BALF and IL-4 in the serum were decreased significantly after inhalation.
*IL13↓,
*TNF-α↓,
*CXCL15↓,
*SOD↑, Hydrogen gas inhalation markedly upregulated the activity of decreased superoxide dismutase
*MDA↓, and significantly attenuated the increased level of malondialdehyde and myeloperoxidase
*MPO↓,
*ROS↓, Hydrogen gas inhalation improves lung function and protects established airway inflammation in the allergic asthmatic mice model which may be associated with the inhibition of oxidative stress process.
*antiOx↑, therapeutic effects of molecular hydrogen on various diseases have been investigated regarding its antioxidation capability [4] and its anti-inflammation [5] and anti-apoptosis
*Inflam↓,
*Apoptosis↓,
*toxicity↓, it is sufficiently mild that it does not disturb metabolic oxidation-reduction reactions or ROS-mediated cell signalling. Thus, it may be a safe and effective antioxidant for pulmonary diseases
*Stroke↓, , accumulating evidence has demonstrated various types of diseases involving oxidative stress, including ischaemic heart disease [7], stroke [8], acute lung injury [9] and inflammatory bowel disease
*Airway↓, Hydrogen gas inhalation decreased lung resistance in the asthmatic mice model
*Neut↓, There was a significant increase in the number of total cells, neutrophils , eosinophils , lymphocytes . Hydrogen gas inhalation resulted in significant reduction in the number of total cells
*Eos↓,
*BALF-Lym↓,
*BALF-Infl↓, Hydrogen gas inhalation attenuated the elevated levels of inflammatory cytokines present in BALF from the asthmatic mouse model
*AirwayM↓, In our study, we found the hydrogen gas inhalation significantly alleviated the pathologic inflammation degree and mucus content in the lung tissue.

7932- H2,    Hydrogen Gas Inhalation Alleviates Airway Inflammation and Oxidative Stress on Ovalbumin-Induced Asthmatic BALB/c Mouse Model
- in-vivo, Asthma, NA
*antiOx↑, Molecular hydrogen (H2) has recently been recognized for its antioxidant and anti-inflammatory properties
*Inflam↓,
*ROS↓, inhaled H2 significantly reduced inflammatory cell infiltration, OS markers, and pro-inflammatory cytokine expression while upregulating antioxidant enzyme activity.
*TAC↑,
*IgE↓, Furthermore, H2 also significantly decreased serum IgE levels, a marker of allergic inflammation.
*Dose↝, 3% H2 gas inhalation on OVA-induced inflammatory airway conditions, body and lung weights were recorded in mice.
*NLR↓, Our results also demonstrated a significant decline in the NLR in the HT group compared to the NT group
*IL4↓, Conversely, the levels of IL-4 (p < 0.001; Figure 4A), IL-5 (p < 0.001; Figure 4B), IL-13 (p < 0.01; Figure 4C), and GM-CSF (p < 0.01; Figure 4F) were significantly lower in the HT group than in the NC group
*IL5↓,
*IL13↓,
*GM-CSF↓,
*NO↓, NO (p < 0.05; Figure 5B) levels were reduced in the HT group compared with those in the NC group
*GPx↑, treatment with 3% H2 significantly increased the GPx activity in the HT group compared to that in the NC group
*Eos↓, In our study, we observed that H2 inhalation reduced neutrophils in the OVA-induced asthmatic BALB/c mouse model

7934- H2,    Hydrogen-generating silicon-based agent is effective in a mouse model of ovalbumin-induced allergic bronchial asthma
- in-vivo, Asthma, NA
*IgE↓, Silicon-based agent tended to decrease the total IgE concentration in serum
*antiOx↑, Hydrogen therapy, which involves the intake of hydrogen as an antioxidant, has been reported to be effective against various oxidative stress-related diseases.
*Eos↓, The administration in the diet of this Si-based agent to a model mouse of allergic bronchial asthma significantly suppressed eosinophil counts in the BALF and reduced inflammatory cell infiltration in the lungs
*BALF-Infl↓,
*IL5↓, the expressions of interleukins 5, and 13 and C–C motif chemokine 11 in lung tissue tended to decreased in the Si group compared with those in the control group
*IL13↓,
*CCL11↓,

7935- TQ,    Nigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial
- Trial, Asthma, NA
*Dose↝, NSO capsules 500 mg twice daily for 4 weeks were used as a supplementary treatment in a randomized, double-blind, placebo-controlled trial in asthmatics
*eff↑, NSO group showed a significant improvement in mean Asthma Control Test score 21.1 (standard deviation = 2.6) versus 19.6 (standard deviation = 3.7) (p = 0.044) and a significant reduction in blood eosinophils by -50 (-155 to -1) versus 15 (-60 to 87)
*Eos↓,
*FEV1↑, NSO improved forced expiratory volume in 1 second as percentage of predicted value by 4 (-1.25 to 8.75) versus 1 (-2 to 5) but non-significant (p = 0.170)

7938- TQ,    The effect of single dose of thymoquinone, the main constituents of Nigella sativa, in guinea pig model of asthma
*Dose↝, Thirty guinea pigs were randomly divided to 3 groups; control (C), sensitized (S) and pretreated group with (TQ); 3 mg/kg, IP (S+TQ)
*Eos↓, Administration of TQ caused significant decline in eosinophil (p<0.001), basophil (p<0.05) and condensable increment in neutrophil, monocyte and lymphocyte count (p<0.001 for all cases) in comparison with S group.
*IFN-γ↑, Treatment with TQ caused a significant increase in blood IFN-γ in the S +TQ group (124.93±2.31) compared to that in the S group
*Inflam↓, The preventive effect of TQ may be due to its ability to suppress airway inflammation which is indicated by Hajhashemi in 2004.
*IL4↓, In the present study, asthma induction increased IL-4 and IFN-γ and TQ administration decreased IL-4 and increased IFN-γ compared with sensitized group.
*antiOx↑, TQ has been shown to have strong antioxidant properties25-28 and to suppress the expression of inducible nitric oxide (NO) synthesis in rat macrophages
*NO↓,
*COX2/PTGS2↓, It has been shown that TQ has inhibitory effects on both the cyclooxygenase and the 5-lipoxygenase pathways of arachidonic acid metabolism and on membrane lipid peroxidation.
*5LO↓,

7940- TQ,    Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation
- in-vivo, Asthma, NA
*Eos↓, TQ before airway challenge of ovalbumin (OVA)-sensitized mice resulted in a marked decrease in lung eosinophilia and the elevated Th2 cytokines observed after airway challenge with OVA antigen;
*Th2↓, TQ attenuates allergic airway inflammation by inhibiting Th2 cytokines and eosinophil infiltration into the airways; thus demonstrating its potential anti-inflammatory role during the allergic response in the lung.
*IgE↓, TQ also decreased the elevated serum levels of OVA-specific IgE and IgG1.
*IgG1↓,
*Inflam↓, TQ significantly inhibited allergen-induced lung eosinophilic inflammation and mucus-producing goblet cells.
*AirwayM↓,
*IL4↓, While TQ showed a significant effect in inhibiting IL-4, IL-5 and IL-13 and some effect in inducing IFN-gamma production in the BAL fluid,
*IL5↓,
*IL13↓,
*IFN-γ↑,

7941- TQ,    Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma
- in-vivo, Asthma, NA
*5LO↓, Administration of TQ before OVA challenge inhibited 5-lipoxygenase, the main enzyme in leukotriene biosynthesis, expression by lung cells and significantly reduced the levels of LTB4 and LTC4.
*LTB4↓,
*LTC4↓,
*Th2↓, This was accompanied by a marked decrease in Th2 cytokines and BAL fluid and lung tissue eosinophilia, all of which are characteristics of airway inflammation.
*Eos↓,
*Inflam↓, These results demonstrate the anti-inflammatory effect of TQ in experimental asthma.


Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Airway↓, 1,   AirwayM↓, 2,   BALF-Infl↓, 2,   BALF-Lym↓, 1,   CCL11↓, 1,   CXCL15↓, 1,   Eos↓, 7,   FEV1↑, 1,   IgE↓, 3,   IgG1↓, 1,   IL13↓, 4,   LTB4↓, 1,   LTC4↓, 1,   NLR↓, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   GPx↑, 1,   MDA↓, 1,   MPO↓, 1,   ROS↓, 2,   SOD↑, 1,   TAC↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   GM-CSF↓, 1,   IFN-γ↑, 2,   IL4↓, 4,   IL5↓, 3,   Inflam↓, 5,   Neut↓, 1,   Th2↓, 2,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,   Dose↝, 3,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 38

Scientific Paper Hit Count for: Eos, Eosinophils
4 Thymoquinone
3 Hydrogen Gas
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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