IgE Cancer Research Results

IgE, Immunoglobulin E: Click to Expand ⟱
Source:
Type:

IgE

Full Name: Immunoglobulin E

Definition: IgE is an antibody isotype involved primarily in allergic immune responses and defense against certain parasites. IgE binds with high affinity to FcεRI receptors on mast cells and basophils.

Asthma relevance: IgE is a major mediator and biomarker of allergic asthma. Allergen-specific IgE binds FcεRI on mast cells and basophils. Subsequent allergen-mediated cross-linking triggers cellular activation and release of histamine, leukotrienes, prostaglandins, and inflammatory cytokines.

Elevated total or allergen-specific IgE is frequently measured in human asthma and in experimental allergic asthma models such as ovalbumin (OVA) and house dust mite (HDM) models.

Direction:
IgE ↑ = generally adverse in allergic asthma
IgE ↓ = generally beneficial when elevated as part of an allergic response

Common measurement contexts: Serum total IgE; plasma IgE; allergen-specific IgE; OVA-specific IgE; HDM-specific IgE

Typical pathway:
IL-4 / IL-13 ↑ → B-cell class switching ↑ → IgE ↑ → FcεRI activation ↑ → mast-cell / basophil degranulation ↑ → histamine + leukotrienes ↑ → bronchoconstriction and airway inflammation ↑



Scientific Papers found: Click to Expand⟱
7926- H2,    Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model
- in-vivo, Asthma, NA
*Dose↝, Hydrogen gas was delivered to the mice through inhalation twice a day (2 h once) for 7 consecutive days
*Airway↓, Hydrogen gas inhalation significantly alleviated OVA-induced airway hyperresponsiveness, inflammation and goblet cell hyperplasia, diminished TH2 response and decreased IL-4 as well as IgE levels, reduced malondialdehyde (MDA) production
*BALF-Infl↓,
*Th2↓,
*IL4↓,
*IgE↓,
*MDA↓,
*SOD↑, increased superoxide dismutase (SOD) activity
*NF-kB↓, hydrogen gas inhalation inhibited NF-κB activation and markedly activated Nrf2 pathway in OVA-induced asthmatic mice.
*NRF2↑,

7932- H2,    Hydrogen Gas Inhalation Alleviates Airway Inflammation and Oxidative Stress on Ovalbumin-Induced Asthmatic BALB/c Mouse Model
- in-vivo, Asthma, NA
*antiOx↑, Molecular hydrogen (H2) has recently been recognized for its antioxidant and anti-inflammatory properties
*Inflam↓,
*ROS↓, inhaled H2 significantly reduced inflammatory cell infiltration, OS markers, and pro-inflammatory cytokine expression while upregulating antioxidant enzyme activity.
*TAC↑,
*IgE↓, Furthermore, H2 also significantly decreased serum IgE levels, a marker of allergic inflammation.
*Dose↝, 3% H2 gas inhalation on OVA-induced inflammatory airway conditions, body and lung weights were recorded in mice.
*NLR↓, Our results also demonstrated a significant decline in the NLR in the HT group compared to the NT group
*IL4↓, Conversely, the levels of IL-4 (p < 0.001; Figure 4A), IL-5 (p < 0.001; Figure 4B), IL-13 (p < 0.01; Figure 4C), and GM-CSF (p < 0.01; Figure 4F) were significantly lower in the HT group than in the NC group
*IL5↓,
*IL13↓,
*GM-CSF↓,
*NO↓, NO (p < 0.05; Figure 5B) levels were reduced in the HT group compared with those in the NC group
*GPx↑, treatment with 3% H2 significantly increased the GPx activity in the HT group compared to that in the NC group
*Eos↓, In our study, we observed that H2 inhalation reduced neutrophils in the OVA-induced asthmatic BALB/c mouse model

7933- H2,    Hydrogen inhalation ameliorates lung inflammation in mice with asthma
- in-vivo, Asthma, NA
*antiOx↑, Hydrogen has been shown to exhibit antioxidant and anti-inflammatory properties that are beneficial for a range of diseases.
*Inflam↓,
*IL4↓, Hydrogen inhalation attenuated the immune response; decreased the levels of IL-4, IL-5 and IL-13;
*IL5↓,
*IL13↓,
*IL10↑, and further increased the mRNA expression levels of Treg-associated cytokines, namely, IL-10 and TGF-β1, thereby bolstering the body's inflammatory resistance mechanisms.
*TGF-β1↑,
*IgE↓, it also reduced total serum IgE levels and malondialdehyde (MDA) production and increased superoxide dismutase (SOD) secretion in lung tissue.
*MDA↓,
*SOD↑,
*Airway↓, Inhalation of hydrogen decreases airway resistance in asthmatic mice

7934- H2,    Hydrogen-generating silicon-based agent is effective in a mouse model of ovalbumin-induced allergic bronchial asthma
- in-vivo, Asthma, NA
*IgE↓, Silicon-based agent tended to decrease the total IgE concentration in serum
*antiOx↑, Hydrogen therapy, which involves the intake of hydrogen as an antioxidant, has been reported to be effective against various oxidative stress-related diseases.
*Eos↓, The administration in the diet of this Si-based agent to a model mouse of allergic bronchial asthma significantly suppressed eosinophil counts in the BALF and reduced inflammatory cell infiltration in the lungs
*BALF-Infl↓,
*IL5↓, the expressions of interleukins 5, and 13 and C–C motif chemokine 11 in lung tissue tended to decreased in the Si group compared with those in the control group
*IL13↓,
*CCL11↓,

7936- TQ,    Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: a randomized controlled trial
- Trial, Asthma, NA
*Dose↝, 1 and 2 g/day of N sativa, respectively, for 3 months along with maintenance inhaled therapy.
*FEV1↑, FEF25-75% and FEV1 (% predicted) increased significantly (P<.05) at both 6 and 12 weeks in the NS-2 group.
*PEF↑, FEF25-75% and FEV1 (% predicted) increased significantly (P<.05) at both 6 and 12 weeks in the NS-2 group.
*IgE↓, FeNO and serum IgE decreased significantly after 12 weeks in both the NS-1 and NS-2 groups vs baseline
*IFN-γ↑, Both doses of N sativa produced a significant increase in the serum IFN-γ at 12 weeks vs baseline
*eff↑, Significantly fewer patients had exacerbations in the NS-1 group
*IL4∅, The levels of IL-4, IL-10, IL-17A and the eotaxins did not change significantly in any of the three groups at any of the follow up visits.
*IL10∅,
*IL17∅,

7939- TQ,    Effects of Nigella sativa and its constituents on inflammatory markers in ovalbumin-induced asthma model: a preclinical systematic review and meta-analysis
- Review, Asthma, NA
*IL4↓, The findings from the meta-analysis indicated that N. sativa and its constituents significantly reduced the levels of interleukin (IL)-4, IL-5, IL-13, and IL-17
*IL5↓,
*IL13↓,
*IL17↓,
*IgE↓, Furthermore, there was a notable decrease in immunoglobulin E (IgE) following the intervention with N. sativa and its active components.
*IFN-γ∅, However, the levels of interferon-gamma (IFN-γ) remained unchanged as a result of the intervention with N. sativa and its active ingredients.
*antiOx↑, modulate the asthma model induced by ovalbumin through their anti-inflammatory and antioxidant effects.
*Inflam↓,

7940- TQ,    Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation
- in-vivo, Asthma, NA
*Eos↓, TQ before airway challenge of ovalbumin (OVA)-sensitized mice resulted in a marked decrease in lung eosinophilia and the elevated Th2 cytokines observed after airway challenge with OVA antigen;
*Th2↓, TQ attenuates allergic airway inflammation by inhibiting Th2 cytokines and eosinophil infiltration into the airways; thus demonstrating its potential anti-inflammatory role during the allergic response in the lung.
*IgE↓, TQ also decreased the elevated serum levels of OVA-specific IgE and IgG1.
*IgG1↓,
*Inflam↓, TQ significantly inhibited allergen-induced lung eosinophilic inflammation and mucus-producing goblet cells.
*AirwayM↓,
*IL4↓, While TQ showed a significant effect in inhibiting IL-4, IL-5 and IL-13 and some effect in inducing IFN-gamma production in the BAL fluid,
*IL5↓,
*IL13↓,
*IFN-γ↑,


Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Airway↓, 2,   AirwayM↓, 1,   BALF-Infl↓, 2,   CCL11↓, 1,   Eos↓, 3,   FEV1↑, 1,   IgE↓, 7,   IgG1↓, 1,   IL13↓, 5,   NLR↓, 1,   PEF↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   GPx↑, 1,   MDA↓, 2,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 2,   TAC↑, 1,  

Migration(tgid=13) ⓘ

TGF-β1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

GM-CSF↓, 1,   IFN-γ↑, 2,   IFN-γ∅, 1,   IL10↑, 1,   IL10∅, 1,   IL17↓, 1,   IL17∅, 1,   IL4↓, 5,   IL4∅, 1,   IL5↓, 5,   Inflam↓, 4,   NF-kB↓, 1,   Th2↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 3,   eff↑, 1,  
Total Targets: 35

Scientific Paper Hit Count for: IgE, Immunoglobulin E
4 Hydrogen Gas
3 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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