MUC5AC Cancer Research Results

MUC5AC, Mucin 5AC: Click to Expand ⟱
Source:
Type:

MUC5AC - Mucin 5AC

Abbreviation: MUC5AC

Type: Secreted gel-forming mucin / epithelial glycoprotein / tumor biomarker

Function: MUC5AC is a large, heavily glycosylated secreted mucin that contributes to formation of the protective mucus layer on epithelial surfaces. It regulates epithelial barrier properties, cell adhesion, host-pathogen interactions, inflammatory signaling, and interactions between epithelial cells and the extracellular environment.

Cancer: ↕ Context-dependent, with increased expression in several major adenocarcinomas. MUC5AC is frequently overexpressed or aberrantly expressed in pancreatic, esophageal, ovarian mucinous, gastric, and selected lung cancers. Elevated MUC5AC can promote tumor-cell survival, stemness, migration, invasion, immune interactions, and tumor progression. In pancreatic cancer, MUC5AC can enhance integrin αvβ5/Src/STAT3/KLF4 signaling and maintain cancer stem-like properties. However, expression and prognostic significance vary substantially by tumor type.
Scientific Papers found: Click to Expand⟱
7929- H2,    Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma
- NA, Asthma, NA
*IL4↓, The results showed that hydrogen-rich saline reduced cell counts and levels of cytokines IL-4, IL-5, IL-13 and TNF-α in BALF.
*IL5↓,
*IL13↓,
*TNF-α↓,
*AirwayM↓, Hydrogen-rich saline treatment also significantly decreased mucus index, collagen deposition, and expression of MUC5AC, collagen III and VEGF.
*MUC5AC↓,
*COL3A1↓,
*VEGF↓,
*NF-kB↓, The ratio of phospho-NF-κB p65 to total NF-κB p65 was much lower in mice treated with hydrogen-rich saline than in untreated mice.
*Inflam↓, These effects of hydrogen-rich saline on airway inflammation and remodeling were dose-dependent


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AirwayM↓, 1,   IL13↓, 1,   MUC5AC↓, 1,  

Migration(tgid=13) ⓘ

COL3A1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL4↓, 1,   IL5↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  
Total Targets: 10

Scientific Paper Hit Count for: MUC5AC, Mucin 5AC
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1737  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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