CCL11 Cancer Research Results

CCL11, C-C Motif Chemokine Ligand 11 / Eotaxin-1: Click to Expand ⟱

Source:

Type:

CCL11 - C-C Motif Chemokine Ligand 11 / Eotaxin-1

Abbreviation: CCL11, Eotaxin-1, SCYA11

Type: CC chemokine / eosinophil chemoattractant

Function: CCL11 is a chemokine that signals primarily through CCR3 and promotes recruitment and activation of eosinophils. It is produced by epithelial cells, fibroblasts, endothelial cells, macrophages, and other cell types in response to inflammatory and type-2 cytokine signaling, including IL-4 and IL-13.

Asthma: ↑ Increased CCL11 is associated with allergic and eosinophilic asthma. Elevated CCL11 promotes CCR3-dependent eosinophil recruitment and activation in the airways and contributes to airway inflammation, mucus hypersecretion, airway hyperresponsiveness, and tissue remodeling.

Favorable Direction in Asthma: ↓ CCL11 expression or signaling is generally favorable because it reduces eosinophil recruitment and allergic airway inflammation.

Scientific Papers found: Click to Expand⟱

7934-

H2,

Hydrogen-generating silicon-based agent is effective in a mouse model of ovalbumin-induced allergic bronchial asthma

in-vivo,

Asthma,

mouse

*IgE↓, *antiOx↑, *Eos↓, *BALF-Infl↓, *IL5↓, *IL13↓, *CCL11↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

BALF-Infl↓, 1, CCL11↓, 1, Eos↓, 1, IgE↓, 1, IL13↓, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL5↓, 1,
Total Targets: 7

Scientific Paper Hit Count for: CCL11, C-C Motif Chemokine Ligand 11 / Eotaxin-1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells