IgG1 Cancer Research Results

IgG1, Immunoglobulin G1: Click to Expand ⟱
Source:
Type:

IgG1 - Immunoglobulin G1

Abbreviation: IgG1

Type: Immunoglobulin subclass / humoral immune biomarker

Function: IgG1 is an immunoglobulin G subclass involved in antigen recognition, immune-complex formation, Fc gamma receptor signaling, complement-related immune responses, and adaptive immunity. Its functional role differs substantially between species and experimental contexts.

Asthma: ↑ In mouse allergic asthma models, increased allergen-specific IgG1 commonly reflects enhanced Th2/type-2 sensitization and is frequently measured alongside IgE as a marker of allergic immune activation. IgG1-containing immune complexes can activate Fcγ receptor-expressing inflammatory cells and contribute to allergic airway responses.

Context: IgG1 can also be protective during allergen immunotherapy. Immunotherapy-induced mouse IgG1 can inhibit ILC2 expansion and eosinophilic airway inflammation through FcγRIIb-mediated inhibitory signaling. Mouse IgG1 in this setting is considered functionally analogous in part to protective human IgG4.

Typical Asthma Study Direction: ↑ Allergen-specific IgG1 generally indicates stronger Th2 sensitization in untreated mouse asthma models; ↓ is commonly interpreted as suppression of the allergic response. This interpretation should not be applied automatically to allergen-immunotherapy studies.
Scientific Papers found: Click to Expand⟱
7940- TQ,    Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation
- in-vivo, Asthma, NA
*Eos↓, TQ before airway challenge of ovalbumin (OVA)-sensitized mice resulted in a marked decrease in lung eosinophilia and the elevated Th2 cytokines observed after airway challenge with OVA antigen;
*Th2↓, TQ attenuates allergic airway inflammation by inhibiting Th2 cytokines and eosinophil infiltration into the airways; thus demonstrating its potential anti-inflammatory role during the allergic response in the lung.
*IgE↓, TQ also decreased the elevated serum levels of OVA-specific IgE and IgG1.
*IgG1↓,
*Inflam↓, TQ significantly inhibited allergen-induced lung eosinophilic inflammation and mucus-producing goblet cells.
*AirwayM↓,
*IL4↓, While TQ showed a significant effect in inhibiting IL-4, IL-5 and IL-13 and some effect in inducing IFN-gamma production in the BAL fluid,
*IL5↓,
*IL13↓,
*IFN-γ↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AirwayM↓, 1,   Eos↓, 1,   IgE↓, 1,   IgG1↓, 1,   IL13↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↑, 1,   IL4↓, 1,   IL5↓, 1,   Inflam↓, 1,   Th2↓, 1,  
Total Targets: 10

Scientific Paper Hit Count for: IgG1, Immunoglobulin G1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1740  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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