LTB4 Cancer Research Results

LTB4, Leukotriene B4: Click to Expand ⟱
Source:
Type:

LTB4 - Leukotriene B4

Abbreviation: LTB4

Type: Eicosanoid / leukotriene / inflammatory lipid mediator

Pathway: Arachidonic acid → 5-LOX/FLAP → LTA4 → LTA4 hydrolase → LTB4

Function: LTB4 is a potent inflammatory lipid mediator derived from arachidonic acid. It signals primarily through BLT1/LTB4R and BLT2/LTB4R2 and strongly promotes chemotaxis, recruitment, adhesion, and activation of neutrophils, monocytes, macrophages, eosinophils, and other leukocytes.

Asthma: ↑ Increased LTB4 contributes to airway inflammation by recruiting and activating inflammatory leukocytes. It is particularly relevant to neutrophilic and severe asthma phenotypes and can contribute to airway hyperresponsiveness and persistent inflammation.

Favorable Direction in Asthma: ↓ LTB4 production or signaling generally indicates reduced inflammatory leukocyte recruitment and airway inflammation.

Cancer: ↕ Context-dependent. LTB4/BLT signaling can promote inflammatory tumor growth, angiogenesis, migration, and metastasis in some settings, but BLT1-dependent recruitment of cytotoxic T cells can also support antitumor immunity.
Scientific Papers found: Click to Expand⟱
7941- TQ,    Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma
- in-vivo, Asthma, NA
*5LO↓, Administration of TQ before OVA challenge inhibited 5-lipoxygenase, the main enzyme in leukotriene biosynthesis, expression by lung cells and significantly reduced the levels of LTB4 and LTC4.
*LTB4↓,
*LTC4↓,
*Th2↓, This was accompanied by a marked decrease in Th2 cytokines and BAL fluid and lung tissue eosinophilia, all of which are characteristics of airway inflammation.
*Eos↓,
*Inflam↓, These results demonstrate the anti-inflammatory effect of TQ in experimental asthma.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Eos↓, 1,   LTB4↓, 1,   LTC4↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   Th2↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: LTB4, Leukotriene B4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1741  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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