LTC4 Cancer Research Results

LTC4, Leukotriene C4: Click to Expand ⟱

Source:

Type:

LTC4 - Leukotriene C4

Abbreviation: LTC4

Type: Cysteinyl leukotriene / eicosanoid inflammatory lipid mediator

Pathway: Arachidonic acid → 5-LOX/FLAP → LTA4 → LTC4 synthase → LTC4 → LTD4 → LTE4

Function: LTC4 is the first cysteinyl leukotriene produced from LTA4 by LTC4 synthase through conjugation with glutathione. After export from cells, LTC4 is sequentially converted to LTD4 and LTE4. Cysteinyl leukotrienes signal primarily through CysLT receptors including CYSLTR1 and CYSLTR2 and regulate airway smooth-muscle contraction, vascular permeability, mucus secretion, eosinophilic inflammation, and tissue remodeling.

Asthma: ↑ Increased LTC4 and downstream cysteinyl leukotriene signaling are strongly associated with allergic and eosinophilic asthma. Elevated LTC4 contributes to bronchoconstriction, mucus hypersecretion, airway edema, eosinophilic inflammation, airway hyperresponsiveness, and remodeling.

Favorable Direction in Asthma: ↓ LTC4 production or cysteinyl leukotriene signaling is generally favorable and reduces bronchoconstriction and allergic airway inflammation.

Cancer: ↕ Context-dependent. LTC4 and downstream cysteinyl leukotrienes can influence proliferation, survival, migration, angiogenesis, inflammation, and tumor-microenvironment signaling. The net effect depends strongly on cancer type and the relative activity of CysLT1 and CysLT2 receptors.

Scientific Papers found: Click to Expand⟱

7941-

TQ,

Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma

in-vivo,

Asthma,

mouse model of allergic asthm

*5LO↓, Administration of TQ before OVA challenge inhibited 5-lipoxygenase, the main enzyme in leukotriene biosynthesis, expression by lung cells and significantly reduced the levels of LTB4 and LTC4.
*LTB4↓,
*LTC4↓,
*Th2↓, This was accompanied by a marked decrease in Th2 cytokines and BAL fluid and lung tissue eosinophilia, all of which are characteristics of airway inflammation.
*Eos↓,
*Inflam↓, These results demonstrate the anti-inflammatory effect of TQ in experimental asthma.

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

Eos↓, 1, LTB4↓, 1, LTC4↓, 1,

Migration(tgid=13) ⓘ

5LO↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1, Th2↓, 1,
Total Targets: 6

Scientific Paper Hit Count for: LTC4, Leukotriene C4

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells