15-LOX/ALOX15 Cancer Research Results

15-LOX/ALOX15, 15-Lipoxygenase-1: Click to Expand ⟱
Source:
Type:

ALOX15 - Arachidonate 15-Lipoxygenase / 15-Lipoxygenase-1

Abbreviation: ALOX15, 15-LOX, 15-LOX-1

Type: Lipoxygenase enzyme / polyunsaturated fatty-acid oxygenase

Function: ALOX15 catalyzes oxygenation of arachidonic acid and other polyunsaturated fatty acids to generate bioactive lipid mediators. Important products include 15-HETE and downstream oxidized phospholipids and specialized lipid mediators. ALOX15 participates in inflammatory signaling, eosinophil biology, epithelial responses, immune-cell migration, tissue remodeling, and inflammation resolution.

Asthma: ↑ ALOX15 expression and activity are increased in type-2 and eosinophilic asthma. IL-4 and IL-13 strongly induce ALOX15 in airway epithelial cells and macrophages. Increased ALOX15-derived lipid mediators promote eosinophil recruitment, goblet-cell differentiation, MUC5AC expression, epithelial inflammation, airway remodeling, and airway hyperresponsiveness.

Favorable Direction in Asthma: ↓ Excess ALOX15 activity is generally favorable when the measured effect reflects suppression of type-2/eosinophilic airway inflammation, although some ALOX15-derived lipids also participate in inflammation resolution.

Cancer: ↕ Context-dependent. ALOX15 can have tumor-promoting or tumor-suppressive effects depending on tissue and lipid products generated. In colorectal cancer, reduced ALOX15 and loss of pro-resolving lipid signaling have been associated with inflammation-driven tumor progression, whereas other ALOX15-derived metabolites may promote malignant signaling in selected cancers.
Scientific Papers found: Click to Expand⟱
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

MYCN↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   BAX↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   iNOS↓, 1,   MAPK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3II↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNMT1↓, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CycB/CCNB1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cMET↓, 1,   GSK‐3β↑, 1,   PI3K↓, 1,   STAT3↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   MMPs↓, 1,   TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   ChemoSen↑, 1,   MRP1/ABCC1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,   RenoP↑, 1,   Risk↓, 1,  
Total Targets: 43

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

MDA↓, 1,   ROS↓, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,   Casp9↓, 1,   JNK↓, 1,   MAPK↓, 1,   p38↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↝, 1,   Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   hepatoP↑, 1,   radioP↑, 1,   toxicity↓, 1,  
Total Targets: 19

Scientific Paper Hit Count for: 15-LOX/ALOX15, 15-Lipoxygenase-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1744  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page