AntiP Cancer Research Results

AntiP, antiparasitic: Click to Expand ⟱
Source:
Type:

Antiparasitic Activity - Activity Against Parasitic Organisms

Type: Therapeutic effect / antimicrobial functional outcome

Function: Antiparasitic activity refers to the ability of a compound, extract, drug, or intervention to inhibit the growth, survival, replication, development, or infectivity of parasitic organisms. Depending on the study, this may include protozoa, helminths, or ectoparasites.

Favorable Direction: ↑ Antiparasitic activity = greater inhibition or killing of parasites and is generally favorable.

Unfavorable Direction: ↓ Antiparasitic activity = reduced effectiveness against parasites.
Scientific Papers found: Click to Expand⟱
8025- IVM,    Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth
- in-vitro, CRC, SW480 - in-vivo, CRC, HCT116
*AntiP↓, Ivermectin, an antiparasitic drug, has been shown to possess anti-inflammation, anti-virus, and antitumor properties.
*Inflam↓,
*AntiViral↑,
AntiTum↑,
TumCP↓, ivermectin dose-dependently inhibited colorectal cancer SW480 and SW1116 cell growth, followed by promoting cell apoptosis and increasing Caspase-3/7 activity.
Apoptosis↑,
Casp3↑,
Casp7↑,
BAX↑, ivermectin upregulated the expression of proapoptotic proteins Bax and cleaved PARP and downregulated antiapoptotic protein Bcl-2.
cl‑PARP↑,
Bcl-2↓,
mt-ROS↑, ivermectin promoted both total and mitochondrial ROS production in a dose-dependent manner,
eff↓, which could be eliminated by administering N-acetyl-l-cysteine (NAC) in CRC cells.
Dose↝, ivermectin at low doses (2.5 and 5 µM) induced CRC cell arrest. Overall, ivermectin suppressed cell proliferation by promoting ROS-mediated mitochondrial apoptosis pathway and inducing S phase arrest in CRC cells,
TumCCA↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

mt-ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp7↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: AntiP, antiparasitic
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1749  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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