RSK2/RPS6KA3/p90RSK2 Cancer Research Results

RSK2/RPS6KA3/p90RSK2, Serine/threonine protein kinase / MAPK-ERK downstream effector: Click to Expand ⟱
Source:
Type:

RPS6KA3 - Ribosomal Protein S6 Kinase A3 / RSK2

Abbreviation: RSK2, RPS6KA3, p90RSK2

Type: Serine/threonine protein kinase / MAPK-ERK downstream effector

Function: RSK2 is a member of the p90 ribosomal S6 kinase family activated primarily downstream of ERK1/2. It regulates transcription, protein synthesis, cell-cycle progression, proliferation, survival, migration, differentiation, and stress responses through phosphorylation of multiple nuclear and cytoplasmic substrates.

Cancer: ↑ Frequently activated or overexpressed in selected cancers and can promote proliferation, survival, migration, invasion, transformation, and treatment resistance downstream of MAPK/ERK signaling. RSK2 inhibition or knockdown can suppress tumor-cell growth and oncogenic signaling in experimental models.
Scientific Papers found: Click to Expand⟱
8161- LapC,    Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells
- in-vitro, ESCC, KYSE-30 - in-vitro, ESCC, KYSE450 - in-vitro, ESCC, KYSE-510
RSK2/RPS6KA3/p90RSK2↓, TumCG↓, Apoptosis↑, Casp3↑, Casp7↑, PARP↑, Cyt‑c↑, BAX↑, p‑CREB↓, ATF1↓, H3↓, CycB/CCNB1↓, cycD1/CCND1↓, p‑CDK2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ATF1↓, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑CREB↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Casp3↑, 1,   Casp7↑, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

p‑CDK2↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: RSK2/RPS6KA3/p90RSK2, Serine/threonine protein kinase / MAPK-ERK downstream effector
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1768  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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