ATF1 Cancer Research Results

ATF1, Activating Transcription Factor 1: Click to Expand ⟱
Source:
Type:

ATF1 - Activating Transcription Factor 1

Type: Transcription factor / CREB-ATF family member

Function: ATF1 is a transcription factor in the CREB/ATF family that binds cAMP-response elements and regulates genes involved in proliferation, survival, differentiation, metabolism, and cellular stress responses. Its transcriptional activity is controlled by phosphorylation and interactions with transcriptional cofactors.

Cancer: ↑ Frequently overexpressed or activated in multiple cancers and associated with increased proliferation, survival, migration, invasion, therapeutic resistance, and poor prognosis. ATF1 also participates directly in oncogenic gene fusions; the EWSR1-ATF1 fusion is a characteristic driver of clear cell sarcoma and occurs in several other rare tumors.
Scientific Papers found: Click to Expand⟱
8161- LapC,    Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells
- in-vitro, ESCC, KYSE-30 - in-vitro, ESCC, KYSE450 - in-vitro, ESCC, KYSE-510
RSK2/RPS6KA3/p90RSK2↓, TumCG↓, Apoptosis↑, Casp3↑, Casp7↑, PARP↑, Cyt‑c↑, BAX↑, p‑CREB↓, ATF1↓, H3↓, CycB/CCNB1↓, cycD1/CCND1↓, p‑CDK2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ATF1↓, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑CREB↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Casp3↑, 1,   Casp7↑, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

p‑CDK2↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ATF1, Activating Transcription Factor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1769  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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