ALDH1A3 Cancer Research Results

ALDH1A3, Aldehyde Dehydrogenase 1 Family Member A3: Click to Expand ⟱
Source:
Type:

ALDH1A3 - Aldehyde Dehydrogenase 1 Family Member A3

Type: Aldehyde dehydrogenase / retinaldehyde dehydrogenase / metabolic enzyme / cancer stem-cell-associated marker

Function: ALDH1A3 is an NAD+-dependent aldehyde dehydrogenase that oxidizes retinaldehyde to retinoic acid and also contributes to detoxification of reactive aldehydes, redox homeostasis, differentiation, cellular metabolism, and stem-cell biology.

Cancer: ↑ Frequently overexpressed or enriched in aggressive and stem-like tumor-cell populations. Increased ALDH1A3 is associated with cancer stemness, proliferation, migration, invasion, metastasis, metabolic adaptation, treatment resistance, and poor prognosis in several malignancies. ALDH1A3 inhibition or knockdown can reduce tumor growth and stem-like properties in experimental models.

Favorable Direction in Cancer: ↓ ALDH1A3 expression or activity is generally favorable in cancers where ALDH1A3 is tumor-promoting.
Scientific Papers found: Click to Expand⟱
8193- LGE,    Targets and pathways involved in the antitumor activity of citral and its stereo-isomers
- Review, Var, NA
TumCP↓, Apoptosis↑, ROS↑, DNAdam↑, MARK4↓, ALDH1A3↓, CSCs↓, chemoR↓, BioAv↓, selectivity↝,
8186- LGE,    Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3
- vitro+vivo, BC, NA
ALDH1A3↓, TumCG↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ALDH1A3↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

MARK4↓, 1,   TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   chemoR↓, 1,   selectivity↝, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ALDH1A3, Aldehyde Dehydrogenase 1 Family Member A3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1774  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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