IGF2BP3/IMP3/KOC Cancer Research Results

IGF2BP3/IMP3/KOC, Insulin-Like Growth Factor 2 mRNA-Binding Protein 3: Click to Expand ⟱
Source:
Type:

IGF2BP3 - Insulin-Like Growth Factor 2 mRNA-Binding Protein 3

Abbreviation: IGF2BP3, IMP3

Alternative Names: IMP3, KOC, KOC1, CT98, VICKZ3

Type: RNA-binding protein / m6A reader / post-transcriptional regulator

Function: IGF2BP3 binds and regulates selected mRNAs and other RNAs, including m6A-modified transcripts, influencing RNA stability, localization and translation. It is highly expressed during embryonic development, is low or absent in most normal adult tissues, and is frequently re-expressed in cancer.

Cancer: ↑ IGF2BP3 is frequently overexpressed in human cancers and generally promotes tumor-cell proliferation, survival, migration, invasion, metastasis, altered metabolism, chemotherapy resistance and immune evasion. High IGF2BP3 expression is commonly associated with aggressive disease and poor prognosis.

Favorable Direction in Cancer: ↓ IGF2BP3 expression or activity is generally favorable where IGF2BP3 functions as an oncogenic RNA-binding protein.
Scientific Papers found: Click to Expand⟱
8214- LCA,    Licochalcone A decreases cancer cell proliferation and enhances ferroptosis in acute myeloid leukemia through suppressing the IGF2BP3/MDM2 cascade
- vitro+vivo, AML, U937
TumCP↓, Ferroptosis↑, IGF2BP3/IMP3/KOC↓, MDM2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IGF2BP3/IMP3/KOC↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↑, 1,   MDM2↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IGF2BP3/IMP3/KOC, Insulin-Like Growth Factor 2 mRNA-Binding Protein 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1779  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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