PRMT6 Cancer Research Results

PRMT6, Protein Arginine Methyltransferase 6: Click to Expand ⟱
Source:
Type:

PRMT6 - Protein Arginine Methyltransferase 6

Abbreviation: PRMT6

Type: Type I protein arginine methyltransferase / epigenetic regulator / histone methyltransferase

Function: PRMT6 catalyzes asymmetric dimethylation of arginine residues on histone and non-histone proteins. A major chromatin mark produced by PRMT6 is H3R2me2a, which can alter transcription through crosstalk with other histone modifications such as H3K4me3. PRMT6 also regulates cell-cycle proteins, signaling proteins, RNA-processing factors, and metabolic enzymes.

Cancer: ↕ Context-dependent. PRMT6 is oncogenic in many cancers, where increased expression or activity can promote proliferation, migration, invasion, epithelial-to-mesenchymal transition, stemness, metabolic reprogramming, and treatment resistance. However, PRMT6 can also act as a tumor suppressor in selected contexts, including hepatocellular carcinoma and melanoma.

Favorable Direction in Cancer: Context-dependent. ↓ PRMT6 may be favorable in tumors where PRMT6 drives oncogenic transcription or signaling, whereas ↑ PRMT6 may be favorable where it suppresses pathways such as RAS-MEK/ERK or represses tumor-promoting genes.
-PRMT6 is up-regulated in human breast cancers and is associated with oncogenesis

Interpretation Note: PRMT6 direction should be assigned according to tumor type and substrate. H3R2me2a ↑ alone should not automatically be interpreted as favorable or unfavorable because PRMT6 can repress either tumor-suppressor or oncogenic genes depending on chromatin context.
Scientific Papers found: Click to Expand⟱
8238- LCA,    Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6
- in-vitro, BC, MCF7 - in-vivo, NA, MCF10
PRMT6↓, EstroRS/ERS↓, selectivity?, P53↑, TumCCA↑, Apoptosis↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

PRMT6↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

EstroRS/ERS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity?, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EstroRS/ERS↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PRMT6, Protein Arginine Methyltransferase 6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1791  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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