CCN2/CTGF Cancer Research Results

CCN2/CTGF, Connective Tissue Growth Factor: Click to Expand ⟱
Source:
Type: prognostic biomarker
CTGF is a matricellular protein that belongs to the CCN (Cyr61/CTGF/Nov) family. It plays a pivotal role in diverse biological processes, including cell adhesion, migration, proliferation, and differentiation. CTGF is also involved in wound healing and fibrosis. In cancer, CTGF’s function is multifaceted, affecting tumor growth, angiogenesis, and the remodeling of the tumor microenvironment.

CTGF is overexpressed in several cancer types, such as pancreatic, breast, and prostate cancers. In these contexts, higher levels of CTGF have been associated with enhanced tumor growth, angiogenesis, and metastasis.

Elevated CTGF expression often correlates with adverse clinical features.

CCN2 - Cellular Communication Network Factor 2 / Connective Tissue Growth Factor

Abbreviation: CCN2, CTGF

Type: Matricellular protein / extracellular signaling protein

Function: CCN2 is a secreted matricellular protein that regulates cell adhesion, migration, proliferation, extracellular-matrix remodeling, fibrosis, angiogenesis, and interactions between tumor cells and stromal cells. It is strongly influenced by signaling pathways including TGF-β, YAP/TAZ, integrins, and growth-factor signaling.

Cancer: ↑ Frequently increased in tumors and tumor-associated stroma. Elevated CCN2 can promote fibrosis, cancer-associated fibroblast activation, extracellular-matrix deposition, tumor-cell survival, invasion, angiogenesis, metastatic niche formation, and resistance to therapy. Its effects are context-dependent, but increased CCN2 is predominantly associated with tumor progression in many solid cancers.
Scientific Papers found: Click to Expand⟱
7907- Api,  IVT,    Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells
- Review, Var, NA
ChemoSen↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, MMP↓, TumMeta↓, MAPK↓, VEGF↓, MMP9↓, TGF-β↓, Inflam↓, COX2/PTGS2↓, IL6↓, NF-kB↓, TumCCA↑, P53↑, cycD1/CCND1↓, BAX↑, Casp↓, Bcl-2↓, CD133↓, Nanog↓, SOX2↓, Akt↓, TumCP↓, TumCMig↓, YAP/TEAD↓, CCN2/CTGF↓, CCN1/CYR61↓, SIRT3↓, SIRT6↓, PCNA↓, DNMT1↓, miR-34a↑,
1117- GBE,    Ginkgobiloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways
- vitro+vivo, Kidney, HK-2
α-SMA↓, COL1↓, TGF-β↓, SMAD2↓, SMAD3↓, p‑SMAD2↓, p‑SMAD3↓, p38↓, p‑p38↓, Vim↓, TIMP1↓, CCN2/CTGF↓, E-cadherin↑, MMP1:TIMP1↑,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
7701- IP6,    Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-β-catenin-ABCG1 signaling pathway
- vitro+vivo, HCC, Hep3B - NA, NA, MHCC-97H
AntiCan↑, ChemoSen↑, LRP6↓, Wnt↓, β-catenin/ZEB1↓, CCN2/CTGF↓, ABCG1↓, TumCP↓, TumCMig↓,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ABCG1↓, 1,   CCN1/CYR61↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

SIRT3↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 2,   Bcl-2↓, 2,   Casp↓, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Fas↑, 1,   FasL↑, 1,   JNK↑, 1,   MAPK↓, 1,   p38↓, 1,   p38↑, 1,   p‑p38↓, 1,   YAP/TEAD↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNMT1↓, 1,   P53↑, 2,   PCNA↓, 2,   SIRT6↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CSCs↓, 1,   LRP6↓, 1,   miR-34a↑, 1,   Nanog↓, 1,   PI3K↓, 1,   SOX2↓, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

CCN2/CTGF↓, 4,   CD31/PECAM-1↓, 1,   COL1↓, 1,   E-cadherin↑, 1,   MMP1:TIMP1↑, 1,   MMP2↓, 1,   MMP9↓, 2,   RAGE↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   TGF-β↓, 2,   TIMP1↓, 1,   TIMP2↑, 1,   TumCMig↓, 2,   TumCP↓, 2,   TumMeta↓, 2,   uPA↓, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 2,   VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 2,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 2,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoPv↑, 1,  
Total Targets: 76

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CCN2/CTGF, Connective Tissue Growth Factor
1 Apigenin (mainly Parsley)
1 Isovitexin
1 Ginkgo biloba
1 Hibiscus sabdariffa
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:211  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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