NFE2L2 Cancer Research Results

NFE2L2, nuclear factor (erythroid-derived 2)-like 2: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
A transcription factor that plays a crucial role in cellular defense mechanisms against oxidative stress and inflammation.
It regulates the expression of various antioxidant and detoxifying enzymes, helping to protect cells from damage caused by reactive oxygen species (ROS).
In many cancers, NRF2 is found to be constitutively activated due to mutations in the NFE2L2 gene or alterations in its regulatory pathways.
Scientific Papers found: Click to Expand⟱
5119- JG,    Juglone Suppresses Inflammation and Oxidative Stress in Colitis Mice
- in-vivo, Nor, NA
*antiOx↑, shows potent antioxidant, antimicrobial, and immunoregulatory activities
*OS↑, JUG treatment significantly ameliorated body weight loss and disease activity index and improved the survival probability, colon length, and tissue damage.
*IL6↓, JUG reversed the DSS-induced up-regulation of proinflammatory cytokines, including interleukin (IL)-6, 12, 21, and 23, and tumor necrosis factor-alpha, and anti-inflammatory cytokines, such as IL-10 and transforming growth factor-beta,
*IL12↓,
*IL23↓,
*TNF-α↓,
*Inflam↓,
*NF-kB↓, the activation of mitochondrial uncoupling protein 2 and phospho-Nuclear Factor-kappa B p65 and the inhibition of the kelch-like ECH-associated protein 1 and NF-E2-related factor 2 induced by DSS were also reversed under JUG administration.
*NFE2L2↓,
*ROS↓, JUG could be a promising agent for UC prevention to regulate inflammatory cytokines and oxidative stress.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   NFE2L2↓, 1,   ROS↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL12↓, 1,   IL23↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

OS↑, 1,  
Total Targets: 11

Scientific Paper Hit Count for: NFE2L2, nuclear factor (erythroid-derived 2)-like 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:217  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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