NRAS Cancer Research Results

NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
NRAS (Neuroblastoma RAS viral oncogene homolog) is a gene that encodes a protein involved in cell signaling pathways that regulate cell growth and differentiation.
When NRAS is mutated or overexpressed, it can lead to uncontrolled cell proliferation and contribute to tumorigenesis.
Scientific Papers found: Click to Expand⟱
85- QC,    Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3)
- in-vitro, Pca, PC3
uPA↓, Quercetin downregulates uPA, uPAR and EGF, EGF-R mRNA expressions.
uPAR↓,
EGFR↓,
NRAS↓,
Jun↓,
NF-kB↓, Quercetin inhibits cell survival factor β-catenin, NF-κB and also proliferative signalling molecules such as p-EGF-R, N-Ras, Raf-1, c.Fos c.Jun and p-c.Jun protein expressions
β-catenin/ZEB1↓,
p38↑,
MAPK↑,
cJun↓,
cFos↓,
Raf↓, Raf-1
TumCI↓, PC-3 cells are treated with quercetin, which inhibits invasion and migration of PC-3 cells.
TumCMig↓,

7908- VT,    Vitexin isolated from Prosopis cineraria leaves induce apoptosis in K-562 leukemia cells via inhibition of the BCR-ABL-Ras-Raf pathway
- in-vitro, AML, NA
MMP↓, Vitexin exhibited cytotoxicity by reducing mitochondrial membrane potential (32.40%) and causing DNA fragmentation (84.15%).
DNAdam↑,
BCR↓, inhibition of cell survival proteins (BCR, ABL, H-RAS, N-RAS, K-RAS and RAF) and expression of apoptotic proteins (p38, BAX and caspase-9) in leukemia cells upon treatment with vitexin.
ABL1↓,
HRAS↓,
NRAS↓,
KRAS↓,
Raf↓,
p38↑,
BAX↑,
Casp9↑,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

ABL1↓, 1,   BCR↓, 1,   MMP↓, 1,   Raf↓, 2,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Casp9↑, 1,   MAPK↑, 1,   p38↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   HRAS↓, 1,   Jun↓, 1,   NRAS↓, 2,  

Migration(tgid=13) ⓘ

KRAS↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   uPA↓, 1,   uPAR↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EGFR↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   KRAS↓, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:225  State#:%  Dir#:1
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