B2M Cancer Research Results

B2M, beta-2-microglobulin: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
B2M Antigen Presentation, Immune Escape, and Biomarker Roles High B2M expression correlated with worse prognosis. Our results indicate that B2M and HLA-A loss occurs frequently in tumors.
B2M is considered a tumor suppressor gene.
Elevated serum B2M is strongly associated with poor prognosis in: Multiple myeloma, Lymphomas (CLL, NHL), and Some leukemias
Dual Nature: Tumor Suppression vs Disease Severity
Loss of B2M (tumor cell)
→ Immune escape, therapy resistance
High B2M (serum)
→ High tumor burden, inflammation, poor prognosis


β2-Microglobulin is essential for anti-tumor immune recognition.
-Loss of B2M in tumor cells enables immune escape and immunotherapy resistance.
-Elevated circulating B2M reflects tumor burden and poor prognosis, especially in hematologic malignancies.


Scientific Papers found: Click to Expand⟱
3421- TQ,    Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer
- Analysis, Nor, NA - in-vivo, Nor, NA - in-vitro, BC, MCF-7 - in-vitro, Nor, HaCaT
HDAC↓, The in silico findings were corroborated with an in vitro analysis, demonstrating the efficient role of TQ in the attenuation of global HDAC activity.
P21↑, reactivation of HDAC target genes (p21 and Maspin), induction of the pro-apoptotic gene Bax, down regulation of the anti-apoptotic gene Bcl-2 and arrest of the cell cycle at the G2/M phase.
Maspin↑,
BAX↑,
B2M↓,
TumCCA↑,
selectivity↑, higher cytotoxicity of TQ towards MCF-7 breast cancer cells in comparison to normal cells indicates the potential of TQ to be an anticancer drug.
*toxicity↓, Fortunately, in the case of normal cells, TQ elicits no lethal effect as that of TSA and almost all cells remained viable even at 100 μM TQ. above findings it is evident that TQ is non-toxic to normal cells
TumCMig↓, TQ inhibits migration and proliferation of breast cancer cells.
TumCP↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

BAX↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,  

Migration ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

B2M↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Clinical Biomarkers ⓘ

B2M↓, 1,   Maspin↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: B2M, beta-2-microglobulin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:24  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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