PDH Cancer Research Results

PDH, mitochondrial pyruvate dehydrogenase (PDH): Click to Expand ⟱
Source:
Type:
-An enzyme complex that plays a crucial role in cellular metabolism, particularly in the conversion of pyruvate to acetyl-CoA, which is then used to produce energy in the form of ATP. -Key enzyme in cellular metabolism that catalyzes the conversion of pyruvate (produced during glycolysis) into acetyl-CoA, which then enters the tricarboxylic acid (TCA) cycle in the mitochondria.
The phosphorylation state of PDH (p-PDH) broadly exists in the cancer cells.
Some cancer cells have been found to inhibit PDH activity, which can lead to increased lactate production and a shift towards glycolysis, even in the presence of oxygen. This is known as the Warburg effect.
-In cancer cells, PDH has been shown to be inhibited.
PDH expression is regulated by various transcription factors, including HIF-1α, c-Myc, and p53.
Scientific Papers found: Click to Expand⟱
5257- 3BP,    Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment
- Review, Var, NA
Glycolysis↓, mt-OXPHOS↓, HK2↓, Cyt‑c↑, Casp3↓, Bcl-2↓, Mcl-1↓, GAPDH↓, LDH↓, PDH↓, TCA↓, GlutaM↓, GSH↓, ATP↓, mitResp↓, ROS↑, ChemoSen↑, toxicity↝,
5266- 3BP,    3-bromopyruvate-based agent KAT-101
- Review, Var, NA
eff↑, Glycolysis↓, OXPHOS↓, ATP↓, TumCP↓, Apoptosis↑, HK2↓, MPT↑, LDH↓, PDH↓,
1640- CA,  MET,    Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines
- in-vitro, Cerv, SiHa
GLS↓, NADPH↓, ROS↑, TumCD↑, AMPK↑, Hif1a↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDH↓, cMyc↓, BAX↓, cycD1/CCND1↓, PDH↓, ROS↑, Apoptosis↑, eff↑, ACLY↓, FASN↓, Bcl-2↓, Glycolysis↓,
1593- Citrate,    Citrate Induces Apoptotic Cell Death: A Promising Way to Treat Gastric Carcinoma?
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
PFK↓, Glycolysis↓, tumCV↓, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, ATP↓, ChemoSen↑, Mcl-1↓, glucoNG↑, FBPase↑, OXPHOS↓, TCA↓, β-oxidation↓, HK2↓, PDH↓, ROS↑,
1576- Citrate,    Targeting citrate as a novel therapeutic strategy in cancer treatment
- Review, Var, NA
TCA↓, T-Cell↝, Glycolysis↓, PKM2↓, PFK2?, SDH↓, PDH↓, β-oxidation↓, CPT1A↓, FASN↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, cl‑PARP↑, Hif1a↓, GLUT1↓, angioG↓, Ca+2↓, ROS↓, eff↓, Dose↓, eff↑, Mcl-1↓, HK2↓, IGF-1R↓, PTEN↑, citrate↓, Dose∅, eff↑, eff↑, eff↑, eff↑,
5195- DCA,  Rad,    Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells
- in-vitro, BC, 4T1 - in-vitro, BC, EMT6
PDKs↑, ROS↑, p‑PDH↓, ECAR↓, lactateProd↓, selectivity↓, RadioS↑,
995- MEL,    Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma
- vitro+vivo, GBM, NA
LDHA↓, MCT4↓, lactateProd↓, i-pH↓, ROS↑, ATP↓, TumCD↑, TumCCA↑, PDH↓, Glycolysis↓, GlucoseCon↓, TumCG↓,
998- PB,    Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect
- in-vivo, NA, NA
p‑PDH↓, PDH↑, PDK1↓, HDAC↓, Glycolysis↓, MMP↓, Apoptosis↑,
3195- SFN,    AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer
- in-vitro, Bladder, UMUC3
ATP↓, Glycolysis↓, OXPHOS↓, HK2↓, PDH↓, AKT1↓, p‑Akt↓,
1888- VitB1/Thiamine,  DCA,    High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate
- in-vitro, PC, SK-N-BE - NA, PC, PANC1
p‑PDH↓, GlucoseCon↓, lactateProd↓, MMP↓, Casp3↑, eff↑, PDKs↓, selectivity↑, TumCG↓, Dose∅, MMP↓, ROS∅, toxicity↑, antiOx↑,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,

Showing Research Papers: 1 to 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↓, 1,   OXPHOS↓, 3,   mt-OXPHOS↓, 1,   ROS↓, 1,   ROS↑, 7,   ROS∅, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 5,   mitResp↓, 1,   MMP↓, 3,   MPT↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   ACLY↓, 1,   AKT1↓, 1,   AMPK↑, 2,   citrate↓, 1,   cMyc↓, 2,   CPT1A↓, 1,   ECAR↓, 1,   FASN↓, 1,   FASN↑, 1,   FBPase↑, 1,   GAPDH↓, 1,   GLS↓, 1,   glucoNG↑, 1,   GlucoseCon↓, 2,   GlucoseCon↑, 1,   GlutaM↓, 1,   Glycolysis↓, 8,   Glycolysis↑, 1,   HK2↓, 6,   HK2↑, 1,   lactateProd↓, 3,   lactateProd↑, 1,   LDH↓, 3,   LDHA↓, 1,   LDHA↑, 1,   MCT4↓, 1,   NADPH↓, 1,   PDH↓, 8,   PDH↑, 1,   p‑PDH↓, 3,   PDK1↓, 1,   PDKs↓, 1,   PDKs↑, 1,   PFK↓, 2,   PFK2?, 1,   PKM2↓, 2,   TCA↓, 4,   β-oxidation↓, 2,  

Cell Death ⓘ

Akt↑, 1,   p‑Akt↓, 1,   p‑Akt↑, 1,   Apoptosis↑, 4,   BAX↓, 1,   Bcl-2↓, 2,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Mcl-1↓, 3,   TumCD↑, 2,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 2,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   IGF-1R↓, 1,   mTORC1↓, 1,   PI3K↑, 1,   PTEN↑, 1,   TumCG↓, 2,  

Migration ⓘ

Ca+2↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 2,   Hif1a↑, 1,  

Barriers & Transport ⓘ

GLUT1↓, 2,   GLUT1↑, 1,   GLUT3↓, 1,  

Immune & Inflammatory Signaling ⓘ

T-Cell↝, 1,  

Cellular Microenvironment ⓘ

i-pH↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   Dose↓, 1,   Dose∅, 2,   eff↓, 6,   eff↑, 8,   RadioS↑, 1,   selectivity↓, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

LDH↓, 3,  

Functional Outcomes ⓘ

toxicity↑, 1,   toxicity↝, 1,  
Total Targets: 98

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PDH, mitochondrial pyruvate dehydrogenase (PDH)
2 3-bromopyruvate
2 Citric Acid
2 Dichloroacetate
1 Caffeic acid
1 Metformin
1 Radiotherapy/Radiation
1 Melatonin
1 Phenylbutyrate
1 Sulforaphane (mainly Broccoli)
1 Vitamin B1/Thiamine
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:245  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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