PI3K/mTOR/ETS2 Cancer Research Results

PI3K/mTOR/ETS2, PI3K/mTOR/ETS2 pathway: Click to Expand ⟱
Source:
Type:
The PI3K/Akt/mTOR signaling pathway is a critical cellular signaling pathway that regulates various cellular processes, including growth, proliferation, survival, and metabolism.
In some cancers, there is an overexpression of PI3K, which can enhance signaling through the pathway even in the absence of growth factor stimulation.
Increased expression of Akt isoforms (Akt1, Akt2, and Akt3) has been observed in several cancers. Both mTORC1 and mTORC2 can be overexpressed in tumors.
Scientific Papers found: Click to Expand⟱
14- CUR,    Curcumin, a Dietary Component, Has Anticancer, Chemosensitization, and Radiosensitization Effects by Down-regulating the MDM2 Oncogene through the PI3K/mTOR/ETS2 Pathway
- vitro+vivo, Pca, PC3
PI3K/mTOR/ETS2↓, Curcumin inhibited PI3K activity, as manifested by changes in the phosphorylation status of Akt
MDM2↓, curcumin reduced the expression of MDM2
P21↑,
Apoptosis↑, Curcumin induced apoptosis and inhibited proliferation of PC3 cells in culture
TumCP↓,
eff↑, Curcumin also inhibited the growth of these cells and enhanced the cytotoxic effects of gemcitabine.
RadioS↑, enhanced the antitumor effects of gemcitabine and radiation


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PI3K/mTOR/ETS2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   MDM2↓, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   RadioS↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PI3K/mTOR/ETS2, PI3K/mTOR/ETS2 pathway
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:255  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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