RNS Cancer Research Results

RNS, reactive nitrogen species: Click to Expand ⟱
Source:
Type:
Reactive nitrogen species (RNS) are chemically reactive molecules that contain nitrogen and can play significant roles in cellular signaling and homeostasis. Like reactive oxygen species (ROS), RNS can have both beneficial and detrimental effects in the context of cancer.
Scientific Papers found: Click to Expand⟱
236- AL,    Allicin: Chemistry and Biological Properties
- Analysis, NA, NA
GSH↓, Bacteria↓, LDL↓, ROS↑, NRF2↑, cognitive↑, memory↑, BP↓, RNS↓,
3677- BBR,    Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *AChE↓, *BChE↓, *MAOA↓, *Aβ↓, *LDL↓, *ROS↓, *RNS↓, *lipid-P↓, *Dose↝, *MAOB↓, *memory↑, *toxicity↓, *BBB↑,
6553- BSB,    Pharmacological and biological effects of alpha-bisabolol: An updated review of the molecular mechanisms
- Review, Nor, NA
*ROS↓, *Inflam↓, *Inf↓, *neuroP↑, *RNS↓, *MDA↓, *GSH↑, *MPO↓, *SOD↑, *Catalase↑, *Bcl-2↑, *BAX↓, *P53↓, *APAF1↓, *Casp3↓, *Casp9↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *ERK↓, *JNK↓, *NF-kB↓, *p38↓, *cognitive↑, *BChE↓,
3588- CUR,    The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
- Review, AD, NA
*cognitive↝, *BioAv↑, *Inflam↓, *COX2↓, *iNOS↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↓, *IL6↓, *IL8↓, *IL12↓, *ROS↓, *RNS↓, *antiOx↑, *BBB↑, *BioAv↓, *cognitive↑, *memory↑, *tau↓, *eff↑,
6317- DRE,    The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells
- in-vitro, Melanoma, A375
Apoptosis↑, selectivity↑, Casp8↑, mt-ROS↑, eff↑, *toxicity↓, Diff↑, TumCP↓, chemoPv↑, *ROS↓, *NO↓, *COX2↓, *RNS↓, TumCI↓, MMP2↓, MMP9↓, p‑Src↓, p‑FAK↓,
3219- EGCG,    Nano-chemotherapeutic efficacy of (−) -epigallocatechin 3-gallate mediating apoptosis in A549 cells: Involvement of reactive oxygen species mediated Nrf2/Keap1signaling
- in-vitro, Lung, A549
ROS↑, RNS↓, MMP↓, NRF2↑, Keap1↓,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, *BioAv↝, *BioAv↝, *BioAv↑, *antiOx↑, *AntiAg↑, *Inflam↓, *AntiBio↑, *MAOA↓, *neuroP↑, *ROS↓, *RNS↓, *eff↑, NF-kB↓, PGE2↓, COX2↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, tumCV↓, PI3K↓, Akt↓, MMPs↓, ChemoSen↑, ALDH↓, *Pain↓, *VGSC↓, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *5LO↓, *chemoPv↑,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27↑, NF-kB↓, COX2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑,
2443- RES,    Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review
- Review, Var, NA
*antiOx↑, *ROS↓, *PTEN↑, *Akt↓, *Catalase↑, *SOD↑, *ERK↓, *GSH↑, *AMPK↑, *FOXO1↝, *RNS↓, *Catalase↑, *cardioP↑, *PI3K↑, *eNOS↑, hepatoP↑,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
3101- VitC,    Vitamin C stimulates or attenuates reactive oxygen and nitrogen species (ROS, RNS) production depending on cell state: Quantitative amperometric measurements of oxidative bursts at PLB-985 and RAW 264.7 cells at the single cell level
- in-vitro, Nor, RAW264.7 - in-vitro, AML, PLB-985
*antiOx↑, *ROS↓, *RNS↓, ROS↑,

Showing Research Papers: 1 to 12 of 12

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 12

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   H2O2↑, 1,   Keap1↓, 1,   lipid-P↑, 1,   NRF2↑, 2,   RNS↓, 2,   ROS↑, 4,   i-ROS↑, 1,   mt-ROS↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   MMP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GlutMet↓, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   APAF1↑, 2,   Apoptosis↓, 1,   Apoptosis↑, 4,   BAD↑, 1,   Bak↑, 1,   BAX↑, 4,   Bcl-2↓, 3,   Bcl-xL↓, 2,   Casp3↑, 3,   Casp8↑, 2,   Casp9↑, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 2,   HGF/c-Met↓, 1,   MAPK↓, 2,   p27↑, 1,   Telomerase↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   DNMTs↓, 1,   P53↑, 2,   PARP↑, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   Diff↑, 1,   EMT↓, 1,   ERK↓, 1,   HDAC↓, 1,   mTOR↓, 1,   PI3K↓, 2,   PTEN↑, 1,   p‑Src↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   E-cadherin↑, 1,   p‑FAK↓, 1,   MMP2↓, 2,   MMP9↓, 3,   MMPs↓, 3,   PKCδ↓, 1,   Slug↓, 1,   Snail↓, 1,   TIMP1↑, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 3,   TumMeta↓, 1,   uPA↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 2,   Inflam↓, 1,   NF-kB↓, 2,   PGE2↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 4,   eff↓, 1,   eff↑, 1,   Half-Life↓, 1,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 1,   radioP↑, 1,   RenoP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 93

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↑, 5,   GPx↑, 2,   GSH↑, 3,   GSTs↑, 2,   H2O2↓, 1,   HDL↑, 1,   lipid-P↓, 1,   MDA↓, 2,   MPO↓, 1,   NADH↓, 1,   NRF2↑, 1,   RNS↓, 10,   ROS↓, 10,   SOD↓, 1,   SOD↑, 4,   SOD1↑, 1,   SOD2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   LDL↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   APAF1↓, 1,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   Casp9↓, 1,   iNOS↓, 4,   JNK↓, 1,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 2,   other↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 2,   FOXO1↝, 1,   IGF-1R↓, 1,   PI3K↑, 1,   PTEN↑, 1,   VGSC↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 2,   AP-1↓, 1,   MMP2↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

eNOS↑, 1,   NO↓, 2,   PDGFR-BB↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 5,   IL1↓, 1,   IL12↓, 1,   IL1β↓, 2,   IL2↓, 1,   IL6↓, 4,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 5,   JAK↓, 1,   NF-kB↓, 3,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 3,   MAOA↓, 3,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   MAOB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 5,   BioAv↝, 4,   Dose↝, 2,   eff↑, 4,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   IL6↓, 4,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 3,   chemoPv↑, 1,   cognitive↑, 3,   cognitive↝, 1,   hepatoP↓, 1,   memory↑, 2,   neuroP↑, 4,   Obesity↓, 1,   Pain↓, 1,   toxicity↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   Inf↓, 1,  
Total Targets: 92

Scientific Paper Hit Count for: RNS, reactive nitrogen species
2 EGCG (Epigallocatechin Gallate)
2 Eugenol
1 Allicin (mainly Garlic)
1 Berberine
1 α-Bisabolol / Chamomile oil
1 Curcumin
1 Dandelion Root
1 Resveratrol
1 Thymol-Thymus vulgaris
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:276  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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