SETBP1 Cancer Research Results

SETBP1, SET binding protein 1: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
SETBP1 (SET binding protein 1) is a gene that encodes a protein involved in various cellular processes, including transcription regulation and cell signaling. Mutations in the SETBP1 gene have been associated with several types of cancer, particularly hematological malignancies.
In some cancers, particularly certain hematological malignancies like acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), SETBP1 may be overexpressed.
Scientific Papers found: Click to Expand⟱
1950- PL,    Increased Expression of FosB through Reactive Oxygen Species Accumulation Functions as Pro-Apoptotic Protein in Piperlongumine Treated MCF7 Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, Lung, A549
selectivity↑, Piperlongumine (PL), a natural alkaloid compound isolated from long pepper (Piper longum), can selectively kill cancer cells, but not normal cells,
ROS↑, by accumulation of reactive oxygen species (ROS)
SETBP1↓, PL downregulates SETDB1 expression
cl‑Casp9↑, enhanced caspase 9 dependent-PARP cleavage during PL-induced cell death.
eff↓, ROS inhibitor NAC (N-acetyl cysteine) recovered SETDB1 expression decreased by PL.
FOSB↑, Decreased SETDB1 expression induced transcriptional activity of FosB during PL treatment. PL treatment dramatically increased FosB promoter activity up to 9-fold


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

cl‑Casp9↑, 1,  

Transcription & Epigenetics ⓘ

SETBP1↓, 1,  

Migration ⓘ

FOSB↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,   selectivity↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SETBP1, SET binding protein 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:279  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

Home Page