TP53 Cancer Research Results

TP53, tumor protein p53: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
TP53 is a gene that encodes the p53 protein, which plays a crucial role in regulating the cell cycle, maintaining genomic stability, and preventing tumor formation. It is often referred to as the "guardian of the genome" due to its role in protecting cells from DNA damage and stress.
Scientific Papers found: Click to Expand⟱
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, eff↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, eff↑, hTERT/TERT↓, cycD1/CCND1↓, eff↑, eff↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
2430- PBG,    The cytotoxic effects of propolis on breast cancer cells involve PI3K/Akt and ERK1/2 pathways, mitochondrial membrane potential, and reactive oxygen species generation
- in-vitro, BC, MDA-MB-231
TumCP↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eff↓, MMP↓, LDH↑, ATP↓, Ca+2↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 7,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   MMP↓, 2,   MMP↑, 1,   mtDam↑, 2,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDH↓, 3,   LDH↑, 1,   PFK↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis?, 1,   Apoptosis↑, 1,   BAD↑, 1,   Bak↑, 1,   BAX↓, 2,   Casp3↓, 2,   Casp3↑, 1,   Casp8↓, 1,   Casp8↑, 1,   Fas↑, 1,   hTERT/TERT↓, 1,   iNOS↑, 1,   Myc↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3B↑, 1,   LC3II↑, 2,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

PARP↑, 1,   TP53↓, 3,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   P21↓, 2,   P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC8↓, 1,   IGF-1R↑, 1,   NOTCH3↓, 1,   STAT3↓, 1,   Wnt↑, 1,  

Migration ⓘ

Ca+2↑, 1,   TIMP1↓, 1,   TumCP↓, 1,   Zeb1↑, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,   eNOS↑, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL10↓, 2,   IL4↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   p65↓, 1,   TLR4↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↓, 1,   Dose∅, 2,   eff↓, 1,   eff↑, 8,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

hTERT/TERT↓, 1,   LDH↓, 3,   LDH↑, 1,   Myc↓, 1,   TP53↓, 3,  

Functional Outcomes ⓘ

AntiCan↑, 1,   OS↑, 1,  
Total Targets: 72

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   MPO↓, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

glucose↓, 1,   LDL↓, 1,  

Cell Death ⓘ

BAX↓, 1,   Cyt‑c↓, 1,  

Migration ⓘ

Ca+2?, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 13

Scientific Paper Hit Count for: TP53, tumor protein p53
2 Propolis -bee glue
1 EGCG (Epigallocatechin Gallate)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:311  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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