TSHR Cancer Research Results

TSHR, thyroid stimulating hormone receptor: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
The thyroid-stimulating hormone receptor (TSHR) is a G protein-coupled receptor that plays a crucial role in regulating thyroid function by mediating the effects of thyroid-stimulating hormone (TSH) on the thyroid gland. TSHR is primarily involved in the synthesis and release of thyroid hormones.
The TSHR gene encodes the thyroid-stimulating hormone receptor (TSHR), which is a G protein-coupled receptor located on the surface of thyroid follicular cells. This receptor is crucial for the regulation of thyroid hormone synthesis and secretion in response to thyroid-stimulating hormone (TSH), which is produced by the pituitary gland.

TSHR expression is well established as a marker of differentiation and prognosis in thyroid cancer, with lower levels generally indicating a worse prognosis.

More aggressive thyroid cancers (poorly differentiated or anaplastic thyroid carcinoma) may show reduced or lost TSHR expression, which is associated with a worse prognosis.
Scientific Papers found: Click to Expand⟱
7635- Ins,    The Role of Inositols in Endocrine and Neuroendocrine Tumors
- Review, Thyroid, NA
*Dose↝, Its most phosphorylated form, inositol hexakisphosphate (IP6), is a highly represented component in vegetables, cereals and dried fruit
VEGF↓, IP6 has been shown to play a role in inducing cell apoptosis in several types of cancer in vitro and in vivo [18] and in inhibiting vascular endothelial growth factor (VEGF) secretion from tumor cells, which influences neoangiogenesis
Imm↑, InsP6 and inositol also modulate the immune system and immunosuppression in the tumor microenvironment, increasing killer cell activity
NK cell↑,
eff↑, A synergistic anticancer action of IP6 combined with inositol was observed in animal models of colon and mammary tumor and metastatic fibrosarcoma
PI3K↓, Inositol and some of its phosphate derivatives (such as InsP6) have been demonstrated to reduce PI3K expression and Akt activation in neoplastic cells by inhibiting Akt phosphorylation
Akt↓,
EMT↓, In breast cancer cells, inositol has been demonstrated to induce an EMT reversion through a significant downregulation of PI3K/Akt activity
MAPK↓, Inositol is able to inhibit the MAPK, PI3K/AKT and Wnt/NFKB pathways, both directly and through a reduction in insulin resistance.
Wnt↓,
NF-kB↓,
IRes↓,
*ROS↓, inositol enhances immunity, reduces oxidative stress and the epithelial–mesenchymal transition.
TumVol↓, supplementation with myo-Ins, with the addition of selenium, induces a morphological change in thyroid nodules classified as class I or II (at low and intermediate risk according to ultrasound classification of the AACE/ACE/AME 2016 guidelines [41])
*TSHR↓, Several clinical studies have demonstrated that treatment with myo-Ins plus selenium is able to significantly reduce TSH levels in patients with subclinical hypothyroidism. higher serum TSH are associated with an increased risk of thyroid cancer


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IRes↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   MAPK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   PI3K↓, 1,   Wnt↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,   NF-kB↓, 1,   NK cell↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  
Total Targets: 3

Scientific Paper Hit Count for: TSHR, thyroid stimulating hormone receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:319  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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