| Source: |
| Type: |
| Normal cells grow and divide in a regulated manner through the cell cycle, which consists of phases (G1, S, G2, and M). Cancer cells often bypass these regulatory mechanisms, leading to uncontrolled proliferation. This can result from mutations in genes that control the cell cycle, such as oncogenes (which promote cell division) and tumor suppressor genes (which inhibit cell division). |
| 2432- | 2DG, | Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth |
| - | in-vitro, | Lung, | H23 | - | in-vitro, | Lung, | KP2 | - | in-vivo, | NA, | NA |
| 5277- | 3BP, | 3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model |
| - | in-vivo, | PC, | Panc02 |
| 5274- | 3BP, | ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1 |
| - | in-vitro, | PC, | NA |
| 5258- | 3BP, | 3-bromopyruvate: Targets and outcomes |
| - | Review, | Var, | NA |
| 5260- | 3BP, | Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer |
| - | in-vivo, | PC, | NA |
| 5472- | AF, | Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion |
| - | in-vitro, | Cerv, | HeLa |
| 5468- | AF, | The gold complex auranofin: new perspectives for cancer therapy |
| - | Review, | Var, | NA |
| 1000- | AG, | 5-FU, | Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation |
| - | vitro+vivo, | BC, | 4T1 |
| 944- | AG, | Astragalus saponins inhibit cell growth, aerobic glycolysis and attenuate the inflammatory response in a DSS-induced colitis model |
| - | vitro+vivo, | CRC, | NA |
| 5444- | AG, | A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine |
| - | Review, | Var, | NA |
| 5431- | AG, | Advances in research on the anti-tumor mechanism of Astragalus polysaccharides |
| - | Review, | Var, | NA |
| 5433- | AG, | Mechanisms of astragalus polysaccharide enhancing STM2457 therapeutic efficacy in m6A-mediated OSCC treatment |
| - | vitro+vivo, | OS, | NA |
| 5434- | AG, | Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview |
| - | Review, | Liver, | NA |
| 5437- | AG, | Modulation of PD-L1 by Astragalus polysaccharide attenuates the induction of melanoma stem cell properties and overcomes immune evasion |
| - | in-vivo, | Melanoma, | B16-F10 |
| 5436- | AG, | Therapeutic Effect of Astragalus Polysaccharides on Hepatocellular Carcinoma H22-Bearing Mice |
| - | in-vivo, | HCC, | NA |
| 4400- | AgNPs, | Rad, | Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells |
| - | in-vitro, | BC, | MCF-7 | - | in-vitro, | Nor, | MCF10 | - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | BT549 | - | in-vivo, | BC, | MDA-MB-231 |
| 4413- | AgNPs, | Anzaroot, | Green synthesis of silver nanoparticles from plant Astragalus fasciculifolius Bioss and evaluating cytotoxic effects on MCF7 human breast cancer cells |
| - | in-vitro, | BC, | MCF-7 |
| 4407- | AgNPs, | Green Synthesis and Characterization of Silver Nanoparticles from Eclipta alba and Its Activity Against Triple-Negative Breast Cancer Cell Line (MDA-MB-231) |
| - | in-vitro, | BC, | MDA-MB-231 |
| 4362- | AgNPs, | Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | CRC, | HT29 | - | in-vivo, | NA, | NA |
| 4426- | AgNPs, | Antiangiogenic properties of silver nanoparticles |
| - | Study, | NA, | NA |
| 4363- | AgNPs, | Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma |
| - | in-vivo, | fibroS, | NA |
| 4551- | AgNPs, | Fenb, | Ångstrom-Scale Silver Particles as a Promising Agent for Low-Toxicity Broad-Spectrum Potent Anticancer Therapy |
| - | in-vivo, | Lung, | NA |
| 4593- | AgNPs, | Chit, | Chitosan-coated silver nanoparticles promoted antibacterial, antibiofilm, wound-healing of murine macrophages and antiproliferation of human breast cancer MCF 7 cells |
| - | in-vitro, | BC, | MCF-7 |
| 374- | AgNPs, | Silver nanoparticles selectively treat triple‐negative breast cancer cells without affecting non‐malignant breast epithelial cells in vitro and in vivo |
| - | in-vitro, | BC, | MCF-7 | - | in-vitro, | BC, | MDA-MB-231 | - | in-vivo, | NA, | NA |
| 367- | AgNPs, | Presence of an Immune System Increases Anti-Tumor Effect of Ag Nanoparticle Treated Mice |
| - | in-vivo, | NA, | NA |
| 358- | AgNPs, | Preparation of triangular silver nanoparticles and their biological effects in the treatment of ovarian cancer |
| - | vitro+vivo, | Ovarian, | SKOV3 |
| 379- | AgNPs, | Effects of green-synthesized silver nanoparticles on lung cancer cells in vitro and grown as xenograft tumors in vivo |
| - | in-vivo, | Lung, | H1299 |
| 380- | AgNPs, | QC, | CA, | Chit, | Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities |
| - | in-vitro, | MG, | U118MG |
| 2647- | AL, | The Mechanism in Gastric Cancer Chemoprevention by Allicin |
| - | Review, | GC, | NA |
| 2648- | AL, | Allicin Inhibits Osteosarcoma Growth by Promoting Oxidative Stress and Autophagy via the Inactivation of the lncRNA MALAT1-miR-376a-Wnt/β-Catenin Signaling Pathway |
| - | in-vitro, | OS, | SaOS2 | - | in-vivo, | OS, | NA |
| 1290- | AL, | Effect of allicin on the expression of Bcl-2 and Bax protein in LM-8 cells |
| - | in-vitro, | OS, | LM8 |
| 544- | AL, | Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations |
| 5168- | AL, | Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells |
| - | in-vitro, | Var, | NA |
| 288- | ALA, | HCA, | CAP, | Octr, | Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin |
| 285- | ALA, | HCA, | Tolerance of oral lipoid acid and hydroxycitrate combination in cancer patients: first approach of the cancer metabolism research group |
| - | Human, | Var, | NA |
| 280- | ALA, | Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition |
| - | in-vivo, | Lung, | A549 |
| 290- | ALA, | HCA, | A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results |
| - | vitro+vivo, | Melanoma, | B16-F10 |
| 291- | ALA, | HCA, | MET, | Dicl, | Metabolic therapies inhibit tumor growth in vivo and in silico |
| - | in-vivo, | Melanoma, | B16-F10 | - | in-vivo, | Lung, | LL/2 (LLC1) | - | in-vivo, | Bladder, | MBT-2 |
| 296- | ALA, | Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo |
| - | vitro+vivo, | neuroblastoma, | SK-N-SH | - | vitro+vivo, | BC, | SkBr3 |
| 297- | ALA, | Insights on the Use of α-Lipoic Acid for Therapeutic Purposes |
| - | Review, | BC, | SkBr3 | - | Review, | neuroblastoma, | SK-N-SH | - | Review, | AD, | NA |
| 258- | ALA, | Effects of α-lipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells |
| - | in-vitro, | BC, | MDA-MB-231 |
| 1124- | ALA, | Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells |
| - | in-vitro, | Thyroid, | BCPAP | - | in-vitro, | Thyroid, | HTH-83 | - | in-vitro, | Thyroid, | CAL-62 | - | in-vitro, | Thyroid, | FTC-133 | - | in-vivo, | NA, | NA |
| 5326- | ALC, | L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro |
| - | vitro+vivo, | Liver, | HepG2 |
| 1349- | And, | Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction |
| - | in-vitro, | Lung, | H460 | - | in-vitro, | Lung, | H1650 |
| 1348- | And, | Andrographolide Inhibits ER-Positive Breast Cancer Growth and Enhances Fulvestrant Efficacy via ROS-FOXM1-ER-α Axis |
| - | in-vitro, | BC, | MCF-7 | - | in-vitro, | BC, | T47D | - | in-vivo, | NA, | NA |
| 4759- | antiOx, | Chemo, | Potential Contributions of Antioxidants to Cancer Therapy: Immunomodulation and Radiosensitization |
| - | Review, | Var, | NA |
| 1151- | Api, | Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study |
| - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | 22Rv1 | - | in-vivo, | NA, | NA |
| 1564- | Api, | Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation |
| - | in-vitro, | Pca, | 22Rv1 | - | in-vivo, | NA, | NA |
| 2634- | Api, | Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells |
| - | in-vitro, | CRC, | HCT116 |
| 2585- | Api, | Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1 |
| - | in-vitro, | ACC, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:323 State#:% Dir#:1
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