BRCA2 Cancer Research Results

BRCA2, BReast CAncer gene 2: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
BRCA1 and BRCA2 are tumor suppressor genes, which, when they function normally, keep tumors from forming.
BRCA2 mutations are associated with an increased risk for:
Breast cancer
Ovarian cancer
Melanoma
Pancreatic cancer
Prostate cancer
Scientific Papers found: Click to Expand⟱
7625- ,    Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair
- in-vitro, sarcoma, NA
TumCD↑, Hyperthermic temperatures (41.8 or 43°C) enhanced significantly trabectedin-related clonogenic cell death and G2/M cell cycle arrest followed by cell type-dependent induction of apoptosis or senescence.
TumCCA↑,
Apoptosis↑,
BRCA2↓, Expression of BRCA2 protein, an integral protein of the HRR machinery, was significantly decreased by heat.
ChemoSen↑, The findings establish BRCA2 degradation by heat as a key factor for a novel treatment strategy that allows targeted chemosensitization to tra

7571- HPT,    Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition
- vitro+vivo, Var, NA
BRCA2↓, mild hyperthermia (41–42.5 °C) induces degradation of BRCA2 and inhibits HR
eff↑, We demonstrate that hyperthermia can be used to sensitize innately HR-proficient tumor cells to PARP-1 inhibitors and that this effect can be enhanced by heat shock protein inhibition.
RadioS↑, HeLa cells, in which the important HR factors XRCC3 or BRCA2 were down-regulated using siRNA, were refractory to further temperature-mediated radiosensitization

7573- HPT,  Rad,    Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies
- vitro+vivo, NA, NA
RadioS↑, Hyperthermia (40-44 °C) effectively sensitises tumours to radiotherapy by locally altering tumour biology
BRCA2↓, We found decreased BRCA2-levels after hyperthermia in all established cell lines and in 91% of all tumours treated ex vivo.

7572- HPT,  Rad,    The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
RadioS↑, Hyperthermia has a number of biological effects that sensitize tumors to radiotherapy in the range between 40-44 °C.
TumCD↑, For treatment temperatures above 41 °C, we found a decrease in cell survival, an increase in sensitization towards irradiation, a decrease of BRCA2 protein levels, and altered RAD51 focus formation.
BRCA2↓,
Dose↝, This study demonstrates that optimal inhibition of HR is achieved by subjecting cells to hyperthermia at 41-43 °C for 30 to 60 minutes.
BloodF↑, The second explanation is that hyperthermia has multiple biological effects, including increased blood flow [33], increased oxidation [34], and activation of the immune system
ROS↑,
Imm↑,

7623- HPT,  Rad,    Enhancing radiosensitisation of BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-i
- Review, Var, NA
BRCA2↓, Recently, BRCA2 was shown to be down-regulated by hyperthermia (HT) temporarily, and this consequently inactivated HR for several hours.
RadioS↑, BRCA2-proficient and deficient cells are radiosensitised by HT, indicating that HT does not exclusively act by inhibition of HR.
eff↑, This combination therapy would be effective for all patients with PARP1-i regardless of their BRCA status.

7626- HPT,  Rad,    Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia
- in-vitro, NA, NA
BRCA2↓, Hyperthermia can transiently degrade BRCA2 and thereby inhibit the homologous recombination pathway.
selectivity↑, Cell survival experiments demonstrated that exposure to hyperthermia radiosensitized the RKO cells, but not the SW‑1573 cells.
RadioS↑, This radiosensitization was at least partly due to the induction of apoptosis, which was only observed in the RKO cells and which may have been induced by BRCA2 degradation
eff↝, genotoxic effect of hyperthermia shortly after combined epxosure (to hyperthermia and radiation) is not observed at 24 h after treatment.


Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   TumCD↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA2↓, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 1,   eff↑, 2,   eff↝, 1,   RadioS↑, 5,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: BRCA2, BReast CAncer gene 2
5 Hyperthermia
4 Radiotherapy/Radiation
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:33  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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