UroPA Cancer Research Results

UroPA, Urokinase plasminogen activator: Click to Expand ⟱
Source: HalifaxProj (suppress)
Type:
Urokinase plasminogen activator (uPA) is an enzyme that plays a significant role in the process of fibrinolysis, which is the breakdown of fibrin in blood clots. It is involved in the conversion of plasminogen to plasmin, leading to the degradation of fibrin and other components of the extracellular matrix. This process is crucial in various physiological and pathological conditions, including wound healing and tissue remodeling.
Elevated levels of uPA and uPAR in tumor tissues and bodily fluids (such as serum) have been associated with a poor prognosis in several types of cancer, including breast, ovarian, and colorectal cancers. The rationale is that increased uPA activity can facilitate tumor cell invasion through the degradation of the extracellular matrix, allowing cancer cells to spread to other tissues.
Scientific Papers found: Click to Expand⟱
7676- iod,    Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)
- in-vivo, BC, NA
TumCP↓, Studies in mammary cancer demonstrated that moderately high concentrations of molecular iodine (I2) have a antiproliferative and apoptotic effect either in vivo as in vitro
Apoptosis↑,
Dose↝, Virgin Sprague-Dawley rats were treated with methyl-nitrosourea (MNU: single dose ip, 50 mg/Kg bw)
other↑, tumoral but not normal mammary tissue contained an elevated basal concentration of AA and significantly more AA-iodinated called 6-iodolactone (6-IL) after chronic I2 treatment.
BloodF↓, Tumors from I2-treated rats showed fewer cells positive to proliferating cell nuclear antigen, lower blood vessel density, as well as decreases in vascular endothelial growth factor, urokinase-type plasminogen activator, and PPAR type alpha (PPARα).
VEGF↓,
UroPA↓,
PPARα↓,
DR4↑, These same tumors showed increases in the cell death markers, TUNEL-positive cells (p < 0.05) and the enzyme caspase-3 (trend), as well as significant induction of PPAR type gamma (PPARγ).
Casp3↑,
PPARγ↑,
antiNeop↑, Together, these data demonstrate that the antineoplasic effect of iodine involves 6-IL formation and PPARγ induction.
Risk↓, Cancer incidence was 37.5% lower in I2-treated than in control rats, whereas the number of tumors per rat and latency were similar for all groups
6IL↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

6IL↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

PPARα↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Casp3↑, 1,   DR4↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,   UroPA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiNeop↑, 1,   Risk↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: UroPA, Urokinase plasminogen activator
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:332  State#:%  Dir#:1
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