GLI3 Cancer Research Results

GLI3, GLI3: Click to Expand ⟱
Source:
Type:
GLI1, GLI2, and GLI3 are key downstream effectors of the Hh signaling pathway, acting as nuclear transcription factors that bind to promoters to regulate target gene expression. Highly expressed genes in human gliomas.
Scientific Papers found: Click to Expand⟱
7991- itraC,    A Phase II Trial of Perioperative Oral Itraconazole for the Management of Low-Risk Basal Cell Carcinoma
- Trial, BCC, NA
Smo↓, Itraconazole has demonstrated clinical activity in such cases by blocking the smoothened (SMO) receptor.
Dose↓, Patients received itraconazole tablets 200 mg twice daily for 60 days before resection.
TumVol↓, median tumour diameter before treatment was 14 mm (IQR 11–16 mm), and after treatment, 13 mm (IQR 11–15 mm), and this reduction in tumour size was statistically significant
Endoglin↓, decrease in the expression of CD105, an endothelial marker (p < 0.0001), was observed
angioG↓, with a decrease in tumour angiogenesis and a favourable safety profile.
toxicity↝,
GLI3↓, there appears to be a trend suggesting that Itraconazole treatment may reduce GLI3 expression (from 0.71 [0.03–9.17] to 0.33 [
toxicity↓, observe that the use of itraconazole was safe, as no changes were observed during or after treatment. Such results are expected, as the safety of itraconazole is already well known


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Smo↓, 1,  

Migration(tgid=13) ⓘ

GLI3↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Endoglin↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GLI3, GLI3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:354  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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