DFF45 Cancer Research Results

DFF45, DNA Fragmentation Factor 45 Gene: Click to Expand ⟱
Source:
Type:
DFF45 was expressed preferably in low-stage neuroblastoma tumors, and to a lesser degree in high-stage neuroblastomas.
Scientific Papers found: Click to Expand⟱
7086- GAR,    Garcinol: An emerging epigenetic modifier with versatile anticancer properties
- Review, Var, NA
AntiCan↑, garcinol has demonstrated huge potential as an anti-cancer agent, inhibiting tumor growth, progression, and metastasis in various cancers, such as lung, liver, pancreas, prostate, breast, colon, and brain cancers.
TumCG↓,
TumMeta↓,
toxicity↓, garcinol offers a safer alternative with broad-spectrum activity and minimal adverse effects.
Apoptosis↑, anti-tumorigenic properties are linked to apoptosis induction, angiogenesis inhibition, and modulation of the tumor microenvironment
angioG↓,
*BioAv↝, nano-delivery systems have improved its bioavailability and therapeutic efficacy, overcoming challenges related to its solubility and stability.
HATs↓, Garcinol primarily targets histone acetyltransferases (HATs), particularly p300 and CBP (CREB-binding protein), leading to structural modifications in these proteins.
p300↓,
CBP↓,
PI3K↓, Garcinol exerts its anticancer effects primarily by modulating key signaling pathways, including the PI3K/AKT, NF-κB, JAK/STAT, and MAPK pathways.
Akt↓,
NF-kB↓,
STAT↓,
mTOR↓, figure 1
DFF45↓,
survivin↓,
N-cadherin↓,
Twist↓,
MMP2↓,
MMP3↓,
MMP9↓,
Mcl-1↓,
EZH2↓,
NOTCH↓,
CXCR4↓,
PGE2↓,
VEGF↓,
mPGES-1↓,
CycB/CCNB1↓,
CDK2↓,
CDK4/6↓,
iNOS↓,
COX2/PTGS2↓,
IL1↓,
TNF-α↓,
PARP↑,
Bcl-2↓,

831- GAR,  CUR,    Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells
- in-vitro, AML, HL-60
Apoptosis↑,
Casp3↑,
MMP↓, 20 microM caused a rapid loss of mitochondrial transmembrane potential
Cyt‑c↑, release of mitochondrial cytochrome c into cytosol
proCasp9↑,
Bcl-2↓,
BAX↑,
PARP↓, degradation of PARP
DNAdam↑,
DFF45↓, through the digestion of DFF-45

2197- SK,    Shikonin derivatives for cancer prevention and therapy
- Review, Var, NA
ROS↑, This compound accumulates in the mitochondria, which leads to the generation of reactive oxygen species (ROS), and deregulates intracellular Ca2+ levels.
Ca+2↑,
BAX↑, shikonin alone by increasing the expression of the pro-apoptotic Bax protein and decreasing the expression of the anti-apoptotic Bcl2 protein
Bcl-2↓,
MMP9↓, This treatment also inhibited metastasis by decreasing the expression of MMP-9 and NF-kB p65 without affecting MMP-2 expression.
NF-kB↓,
PKM2↓, Figure 4
Hif1a↓,
NRF2↓,
P53↑,
DNMT1↓,
MDR1↓,
COX2/PTGS2↓,
VEGF↓,
EMT↓,
MMP7↓,
MMP13↓,
uPA↓,
RIP1↑,
RIP3↑,
Casp3↑,
Casp7↑,
Casp9↑,
P21↓,
DFF45↓,
TRAIL↑,
PTEN↑,
mTOR↓,
AR↓,
FAK↓,
Src↓,
Myc↓,
RadioS↑, shikonin acted as a radiosensitizer because of the high ROS production it induced.


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 2,   BAX↑, 2,   Bcl-2↓, 3,   Casp3↑, 2,   Casp7↑, 1,   Casp9↑, 1,   proCasp9↑, 1,   CBP↓, 1,   Cyt‑c↑, 1,   iNOS↓, 1,   Mcl-1↓, 1,   Myc↓, 1,   RIP1↑, 1,   survivin↓, 1,   TRAIL↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   HATs↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↓, 3,   DNAdam↑, 1,   DNMT1↓, 1,   P53↑, 1,   PARP↓, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CycB/CCNB1↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   mTOR↓, 2,   NOTCH↓, 1,   p300↓, 1,   PI3K↓, 1,   PTEN↑, 1,   Src↓, 1,   STAT↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   CDK4/6↓, 1,   FAK↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 2,   N-cadherin↓, 1,   RIP3↑, 1,   TumMeta↓, 1,   Twist↓, 1,   uPA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   CXCR4↓, 1,   IL1↓, 1,   mPGES-1↓, 1,   NF-kB↓, 2,   PGE2↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

MDR1↓, 1,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EZH2↓, 1,   Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   toxicity↓, 1,  
Total Targets: 71

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,  
Total Targets: 1

Scientific Paper Hit Count for: DFF45, DNA Fragmentation Factor 45 Gene
2 Garcinol
1 Curcumin
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:380  State#:%  Dir#:1
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