TNFR 1 Cancer Research Results

TNFR 1, Tumor necrosis factor receptor 1,: Click to Expand ⟱

Source:

Type:

TNFR-1 is an important member of the death receptor family that shares the capability of inducing apoptotic cell death.

TNFR1 (p55): Often expressed ubiquitously, TNFR1 can mediate both apoptotic and survival signals. In some cancers, its upregulation has been associated with increased inflammatory signaling and may contribute to tumor progression through NF-κB activation.

Scientific Papers found: Click to Expand⟱

6673-

Deg,

Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion

NF-kB↓, constitutive NF-kappaB activation was also blocked by deguelin.
IKKα↓, occurred through the inhibition of the activation of IkappaBalpha kinase, leading to sequential suppression of IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation, p65 nuclear translocation, and NF-kappaB-dependent reporter ge
TNFR 1↓, Deguelin also suppressed the NF-kappaB reporter activity induced by TNFR1, TNFR-associated death domain, TNFR-associated factor 2, and IkappaBalpha kinase, but not that induced by p65.
TumCP↓, down-regulation of gene products involved in cell survival, proliferation, and invasion.
TumCI↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death(tgid=5) ⓘ

TNFR 1↓, 1,

Migration(tgid=13) ⓘ

TumCI↓, 1, TumCP↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

IKKα↓, 1, NF-kB↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: TNFR 1, Tumor necrosis factor receptor 1,

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells