NKX3.1 Cancer Research Results

NKX3.1, Homeobox protein Nkx-3.1: Click to Expand ⟱
Source:
Type:
NKX3.1 is a prostatic tumor suppressor gene located on chromosome 8p. Commonly down-regulated in human prostate cancer.
NKX3.1 is a homeobox transcription factor that is normally highly expressed in prostate luminal epithelial cells.

– During prostate tumorigenesis, NKX3.1 expression is frequently downregulated or lost, particularly in higher-grade lesions and advanced disease.
Reduced or absent NKX3.1 expression is generally associated with poor prognosis.
Loss of NKX3.1 leads to:
-Increased oxidative DNA damage
-Impaired DNA repair fidelity
-Dedifferentiation of prostate epithelium
-Increased susceptibility to oncogenic transformation (e.g., cooperation with PTEN loss)

NKX3.1 loss does not drive proliferation directly—it removes safeguards that normally restrain malignant evolution.


Scientific Papers found: Click to Expand⟱
70- QC,    Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
PSA↓, quercetin inhibited the secretion of the prostate-specific, androgen-regulated tumor markers, PSA and hK2
AR↓, Quercetin inhibits the expression of AR protein
NKX3.1↓, Quercetin can also significantly down-regulate the expression of another prostate-specific gene, NKX3.1,
HK2↓, Quercetin inhibits PSA and hK2 secretion

75- QC,  ENZ,    Quercetin targets hnRNPA1 to overcome enzalutamide resistance in prostate cancer cells
- in-vitro, Pca, HEK293 - in-vitro, NA, 22Rv1 - in-vitro, NA, C4-2B
hnRNPA1↓, quercetin downregulates hnRNPA1 expression
PSA↓,
NKX3.1↓,
FKBP5↓,
UBE2C↓,
AR-FL↓, FL AR
AR-V7↑, downregulates the expression of AR-V7, antagonizes androgen receptor signaling
AR↓, Quercetin downregulates androgen receptor signaling
eff↑, Quercetin resensitizes enzalutamide-resistant xenografts to enzalutamide in vivo
TumVol↓,
BioAv↓, The bioavailability of quercetin is low as it is present in glycosylated form, which can be readily metabolized by enzymes in the gut and liver, leading to low systemic concentrations in the body


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

HK2↓, 1,  

DNA Damage & Repair ⓘ

NKX3.1↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

AR-FL↓, 1,   AR-V7↑, 1,  

Migration ⓘ

hnRNPA1↓, 1,  

Immune & Inflammatory Signaling ⓘ

PSA↓, 2,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   FKBP5↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 2,   PSA↓, 2,  

Functional Outcomes ⓘ

TumVol↓, 1,   UBE2C↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NKX3.1, Homeobox protein Nkx-3.1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:387  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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