hnRNPA1 Cancer Research Results

hnRNPA1, Heterogeneous nuclear ribonucleoprotein A: Click to Expand ⟱
Source:
Type:
Heterogeneous nuclear ribonucleoprotein A/B (hnRNPA/B) is one of the core members of the RNA binding protein (RBP) hnRNPs family, including four main subtypes, A0, A1, A2/B1 and A3, which share the similar structure and functions.
hnRNPA1 was highly expressed in gastric cancer tissues, which promote proliferation, migration and EMT of gastric cancer cells. Down-regulation of HNRNPA1 could suppress tumorigenesis by cell cycle arrest or by inducing apoptosis in cancer cells.

Oncogenic Potential:
hnRNPA1 has been shown to have oncogenic properties in certain contexts, promoting cell proliferation and survival.
Its dysregulation can lead to alternative splicing events that contribute to cancer progression and metastasis.

Its overexpression is associated with various cancers, including breast, lung, colorectal, and prostate cancers, often correlating with poor prognosis and aggressive tumor behavior. As a potential therapeutic target and biomarker, hnRNPA1 represents an important area of research in oncology.
Scientific Papers found: Click to Expand⟱
6587- EU,    Eurycoma longifolia, A Potential Phytomedicine for the Treatment of Cancer: Evidence of p53-mediated Apoptosis in Cancerous Cells
- in-vitro, Lung, A549 - in-vitro, BC, MCF7
AntiCan↑, Eurycoma longifolia, displayed a strong dose-dependent anticancer efficacy against lung carcinoma (A-549 cells) and breast cancer (MCF-7 cells);
Apoptosis↑, prime mode of cytotoxicity of Eurycoma longifolia and its medicinal compounds is the induction of apoptosis (programmed cell death) via the up-regulation of the expression of p53 (tumor suppressor protein)
P53↑,
BAX↑, and pro-apoptotic protein (Bax) and downregulation of the expression of anti-apoptotic protein (Bcl-2).
Bcl-2↓,
PHB↓, A remarkable alleviation in the mRNA expression of various cancer-associated biomarkers including heterogeneous nuclear ribonucleoprotein (hnRNP), prohibitin (PHB), annexin-1 (ANX1) and endoplasmic reticulum protein-28 (ERp28) has also been evidenced
ANXA1↓,
hnRNPA1↓,

93- QC,    Chemical Proteomics Identifies Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A1 as the Molecular Target of Quercetin in Its Anti-cancer Effects in PC-3 Cells
- in-vitro, Pca, PC3
hnRNPA1↓, We found that quercetin bound the C-terminal region of hnRNPA1, impairing the ability of hnRNPA1 to shuttle between the nucleus and cytoplasm and ultimately resulting in its cytoplasmic retention.
Casp3↑, activated caspase-3/7
Casp7↑,
TumCD↑, quercetin induced cell death in a time- and concentration-dependent manner.
IAP1↓, We found quercetin mediated cytoplasmic accumulation of hnRNPA1, resulting in decreased cIAP1 protein levels.

75- QC,  ENZ,    Quercetin targets hnRNPA1 to overcome enzalutamide resistance in prostate cancer cells
- in-vitro, Pca, HEK293 - in-vitro, NA, 22Rv1 - in-vitro, NA, C4-2B
hnRNPA1↓, quercetin downregulates hnRNPA1 expression
PSA↓,
NKX3.1↓,
FKBP5↓,
UBE2C↓,
AR-FL↓, FL AR
AR-V7↑, downregulates the expression of AR-V7, antagonizes androgen receptor signaling
AR↓, Quercetin downregulates androgen receptor signaling
eff↑, Quercetin resensitizes enzalutamide-resistant xenografts to enzalutamide in vivo
TumVol↓,
BioAv↓, The bioavailability of quercetin is low as it is present in glycosylated form, which can be readily metabolized by enzymes in the gut and liver, leading to low systemic concentrations in the body


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

PHB↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp7↑, 1,   IAP1↓, 1,   TumCD↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

NKX3.1↓, 1,   P53↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

AR-FL↓, 1,   AR-V7↑, 1,  

Migration(tgid=13) ⓘ

hnRNPA1↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   PSA↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   FKBP5↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   TumVol↓, 1,   UBE2C↓, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: hnRNPA1, Heterogeneous nuclear ribonucleoprotein A
2 Quercetin
1 Eurycomanone
1 enzalutamide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:388  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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