IMPDH2 Cancer Research Results

IMPDH2, inosine monophosphate dehydrogenase 2: Click to Expand ⟱
Source:
Type:
IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways. IMPDH2 expression has been found to be vastly dysregulated in several cancer types, promoting pro-tumorigenic phenotypes and leading to an elevated IMPDH2/IMPDH1 ratio.

Many cancers have high levels of IMPDH2 and is associated with increased tumor proliferation, aggressiveness, and poorer overall survival. Its expression often correlates with a more aggressive tumor phenotype.
Scientific Papers found: Click to Expand⟱
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↑, Fas↓, Hsc70↓, Hif1a↓, Mcl-1↓, HSP90↓, FLT4↓, EphB4↓, DNA-PK↓, PARP1↓, ATM↓, XIAP↝, PLC↓, GnT-V↝, heparanase↝, NM23↑, CSR1↑, SPP1↓, DNMT1↓, HDAC4↓, CXCR4↓, β-catenin/ZEB1↓, FBXW7↝, AMACR↓, cycD1/CCND1↓, IGF-1R↓, IMPDH1↓, IMPDH2↓, HEC1↓, NHE1↓, NOS2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

XIAP↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMACR↓, 1,  

Cell Death(tgid=5) ⓘ

aSmase↝, 1,   CSR1↑, 1,   Diablo↑, 1,   Fas↓, 1,   Mcl-1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

SPP1↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

Hsc70↓, 1,   HSP90↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   DNA-PK↓, 1,   DNMT1↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FBXW7↝, 1,   HDAC4↓, 1,   IGF-1R↓, 1,  

Migration(tgid=13) ⓘ

EphB4↓, 1,   GnT-V↝, 1,   heparanase↝, 1,   NM23↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

FLT4↓, 1,   Hif1a↓, 1,  

Barriers & Transport(tgid=15) ⓘ

NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CXCR4↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

PLC↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

HEC1↓, 1,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

IMPDH1↓, 1,   IMPDH2↓, 1,  
Total Targets: 32

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IMPDH2, inosine monophosphate dehydrogenase 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:411  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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