LAMA5 Cancer Research Results

LAMA5, laminin alpha 5: Click to Expand ⟱
Source:
Type: gene
The LAMA5 gene is a gene that encodes for the laminin alpha 5 chain, a protein that is part of the laminin family. Laminins are high-molecular weight glycoproteins that are a major component of the basement membrane, a layer of tissue that separates epithelial cells from the underlying connective tissue.
Overexpressed in: Breast, lung, CRC, Prostate
Scientific Papers found: Click to Expand⟱
439- CUR,    Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway
- in-vitro, CRC, LGR5
Apoptosis↑,
TumAuto↑,
GP1BB↓,
COL9A3↓,
COMP↓,
AGRN↓,
ITGB4↓,
LAMA5↓, curcumin inhibited the extracellular matrix (ECM)-receptor interaction pathway via the downregulation of the following genes: GP1BB, COL9A3, COMP, AGRN, ITGB4, LAMA5, COL2A1, ITGB6, ITGA1, and TNC.
COL2A1↓,
ITGB6↓,
LGR5↓,
TFAP2A↓,
ECM/TCF↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

COMP↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

TFAP2A↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

LGR5↓, 1,  

Migration ⓘ

AGRN↓, 1,   COL2A1↓, 1,   COL9A3↓, 1,   GP1BB↓, 1,   ITGB4↓, 1,   ITGB6↓, 1,   LAMA5↓, 1,  

Angiogenesis & Vasculature ⓘ

ECM/TCF↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LAMA5, laminin alpha 5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:423  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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