IFN-γ Cancer Research Results

IFN-γ, Interferon-γ: Click to Expand ⟱
Source:
Type:
Plays a key role in activation of cellular immunity and subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro-apoptotic and antiproliferative functions, IFN-γ is considered potentially useful for adjuvant immunotherapy for different types of cancer.
Moreover, it IFN-γ may inhibit angiogenesis in tumor tissue, induce regulatory T-cell apoptosis, and/or stimulate the activity of M1 proinflammatory macrophages to overcome tumor progression.
However, the current understanding of the roles of IFN-γ in the tumor microenvironment (TME) may be misleading in terms of its clinical application.

IFN-γ is often expressed in the tumor microenvironment, particularly in response to immune cell infiltration. Its expression can be influenced by the presence of tumor-infiltrating lymphocytes (TILs) and other immune cells.
High levels of IFN-γ are typically associated with a Th1 immune response, which is generally considered beneficial for anti-tumor immunity.

Tumor Suppression:
In many cases, IFN-γ has tumor-suppressive effects, as it can inhibit tumor cell proliferation and induce apoptosis in certain cancer types.
Scientific Papers found: Click to Expand⟱
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
4810- ASTX,    Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, selectivity↑, *BDNF↑, *ROS↓, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓, BAX⇅, Bcl-2↓, *antiOx↑, radioP↑, ChemoSen↑,
5419- ASTX,    Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiDiabetic↓, AntiCan↑, *lipid-P↓, TumCP↓, Apoptosis↑, TumCCA↑, *SOD↑, *PGE2↓, *NO↓, *IL8↓, *IFN-γ↓, *cardioP↑, *NF-kB↓, *TNF-α↓, *BioAv↑,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1↑, IL2↓, IL4↓, IFN-γ↓, COX2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
741- Bor,    Boron Derivatives Inhibit the Proliferation of Breast Cancer Cells and Affect Tumor-Specific T Cell Activity In Vitro by Distinct Mechanisms
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
MOB1↓, PD-L1↑, p‑YAP/TEAD↝, IFN-γ↓, sFasL↑, Perforin↓, GranA↓, GranB↓, GNLY↓, PD-1↑,
5742- Buty,    Butyrate: A Double-Edged Sword for Health?
- Review, Var, NA
HCAR2↑, Inflam↓, HDAC↓, *IFN-γ↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↑, *TNF-β↑, *NF-kB↓, *ROS↓, PPARγ↓, Weight↓,
3854- CAP,    Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
- in-vivo, AD, NA
*Aβ↓, *cognitive↑, *APP↓, *MMP-10↝, *p‑tau↓, *Inflam↓, *neuroP↑, *Risk↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *PPARα↑,
5932- CAR,    Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome
- in-vivo, IBD, NA - in-vivo, Park, NA
*GutMicro↑, Risk↓, *Inflam↓, *antiOx↓, *ZO-1↑, *iNOS↓, *IL6↓, *NO↓, *PGE2↓, *memory↑, *TLR4↓, *NF-kB↓, *IBI↑, *CLDN3↑, *CLDN1↑, *MUC1↑, *OCLN↑, *iNOS↑, *COX2↓, *IFN-γ↓, IL1β↓, ADAM10?,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
423- CUR,    Inhibition of TLR4/TRIF/IRF3 Signaling Pathway by Curcumin in Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
TLR4↓, IRF3↓, IFN-γ↓, TRIF↓,
5487- EP,    High-frequency irreversible electroporation improves survival and immune cell infiltration in rodents with malignant gliomas
- in-vivo, GBM, NA
OS↑, CellMemb↑, Imm↑, Inflam↓, necrosis↑, Pyro↑, eff↑, IL2↑, IL6↑, IL17↑, IFN-γ↓,
4346- H2,    Medical Application of Hydrogen in Hematological Diseases
- Review, NA, NA
*AntiAg↑, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓,
1004- HNK,  RAPA,    Honokiol downregulates PD-L1 expression and enhances antitumor effects of mTOR inhibitors in renal cancer cells
- in-vitro, RCC, NA
Apoptosis↑, TumCCA↑, ROS↑, PD-L1↓, IFN-γ↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
3529- Lyco,    The antioxidant and anti-inflammatory properties of lycopene in mice lungs exposed to cigarette smoke
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *ROS↓, *TNF-α↓, *IFN-γ↓, IL10↓,
228- MFrot,  MF,    Rotating magnetic field ameliorates experimental autoimmune encephalomyelitis by promoting T cell peripheral accumulation and regulating the balance of Treg and Th1/Th17
- NA, MS, NA
*CD4+↑, *MCP1↓, RANTES↓, *MIP‑1α↓, *Treg lymp↓, *IFN-γ↓, *IL17↓, *CXCc↓,
220- MFrot,  MF,    Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation
- in-vitro, Melanoma, B16-F10
OS↑, DCells↑, T-Cell↑, Apoptosis↑, IL1↑, IFN-γ↓, IL10↑, TumCG↓, ROS↑, TumCP↓, TumCCA↑, ChrMod↑, CXCL9↓, CXCL12↓, CD4+↑, CD8+↑,
1164- PI,    Inhibition of T cell activation by the phytochemical piperine
- in-vitro, Nor, NA
*other↓, *CD25+↓, *IFN-γ↓, *IL2↓, *IL4↓, *IL17↓, *CD69↓, *CTLA-4↓, *p‑ERK↓, *IKKα↓,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
ROS↑, GSH↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, eff↑, HIF-1↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
4499- Se,    Selenium and Selenoproteins in Gut Inflammation—A Review
- Review, IBD, NA
*Inflam↓, *IL2↓, *TNF-α↓, *IFN-γ↓, *PPARγ↓,
1432- SFN,    Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients with multiple atypical nevi
- Human, Melanoma, NA
other↑, decorin↑, *toxicity↓, IP-10/CXCL-10↓, MCP1↓, CXCL9↓, MIP-1β↓, IFN-γ↓,
3314- SIL,    Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review
- Review, NA, NA
*antiOx↑, *hepatoP↑, *Half-Life↑, *ROS↓, *GSH↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *IFN-γ↓, *IL2↓, *IL4↓, *NF-kB↓, *iNOS↓, *OATPs↓, *OCT4↓, *Inflam↓, *PGE2↓, MMPs↓, VEGF↓, angioG↓, STAT3↓, *ALAT↓, *AST↓, Dose↝,
3648- SIL,    Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years
- Review, NA, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *necrosis↓, *hepatoP↑, *IL1↓, *IL6↓, *TNF-α↓, *IFN-γ↓, MAPK↓, Apoptosis↑, Cyt‑c↑, Casp3↑, Casp9↑, *PPARγ↑, *GLUT4↑, *HSPs↓, *HSP27↑, *Trx↑, *SIRT1↑, *ALAT↓, *GSH↑, *lipid-P↓, *TNF-α↓, TumCG↓, P21↑, CDK4↑,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, NA, NA
*P-gp↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
3300- SIL,    Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy
- Review, Var, NA
*ROS↓, *SOD↑, *hepatoP↑, *AST↓, *ALAT↓, *lipid-P↓, *GSH↑, *Catalase↑, *GSTs↑, *GSR↑, *TNF-α↓, *IFN-γ↓, *IL4↓, *IL2↓, *NF-kB↓, *IL10↑, *Inflam↓, COX2↓, Apoptosis↑, ChemoSen↑, PGE2↓, VEGF↓,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3042- SK,    The protective effects of Shikonin on lipopolysaccharide/D -galactosamine-induced acute liver injury via inhibiting MAPK and NF-kB and activating Nrf2/HO-1 signaling pathways
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *IFN-γ↓, *ALAT↓, *AST↓, *MPO↓, *ROS↓, *JNK↓, *ERK↓, *p38↓, *NF-kB↓, *p‑IKKα↓, *SOD↑, *GSH↑, *HO-1↑, *NRF2↑, *hepatoP↑,
1049- SK,    Shikonin inhibits immune checkpoint PD-L1 expression on macrophage in sepsis by modulating PKM2
- in-vivo, NA, NA
TNF-α↓, IL6↓, IFN-γ↓, IL1β↓, PD-L1↓, p‑PKM2↓,
3410- TQ,    Anti-inflammatory effects of thymoquinone and its protective effects against several diseases
- Review, Arthritis, NA
*Inflam↓, *antiOx↑, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL6↓, *TNF-α↓, *IFN-γ↓, *PGE2↓, *cardioP↑, *Catalase↑, *SOD↑, *Thiols↑, *neuroP↑, *IL12↓, *MCP1↓, *CXCc↓, *ROS↓,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, eff↑, DNAdam↑, *iNOS↓,
3112- VitC,    Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
- Review, Nor, NA
*ROS↓, *antiOx↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *AP-1↑, *Inflam↓, *CRP↓, IFN-γ↓,

Showing Research Papers: 1 to 34 of 34

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 34

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   CYP1A1↓, 1,   GSH↓, 4,   HO-1↓, 2,   HO-1↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 1,   NRF2↓, 1,   NRF2↑, 2,   ROS↑, 8,   ROS⇅, 1,   SOD↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   CDC2↓, 1,   MMP↓, 4,   MPT↑, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

ACSL4↑, 1,   cMyc↓, 2,   p‑cMyc↑, 1,   FASN↓, 1,   PI3K/Akt↓, 1,   p‑PKM2↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 4,   APAF1↑, 1,   Apoptosis↑, 9,   BAX↑, 5,   BAX⇅, 1,   Bcl-2↓, 6,   Casp↑, 2,   Casp10↑, 1,   Casp3↓, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 3,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 4,   DR5↑, 2,   Fas↑, 2,   GranA↓, 1,   GranB↓, 1,   hTERT/TERT↓, 1,   iNOS↓, 6,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   MDM2↓, 1,   necrosis↑, 1,   NICD↓, 1,   p27↑, 1,   p38↓, 1,   Perforin↓, 1,   Pyro↑, 1,   sFasL↑, 1,   survivin↓, 3,   Telomerase↓, 1,   TNFR 1↑, 1,   TRAILR↑, 1,   YAP/TEAD↓, 1,   p‑YAP/TEAD↝, 1,  

Kinase & Signal Transduction ⓘ

HCAR2↑, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

ChrMod↑, 1,   other↓, 2,   other↑, 1,   p‑pRB↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   HSP27↓, 2,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 2,   LC3B-II↑, 1,   LC3I↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DFF45↑, 1,   DNAdam↑, 3,   P53↑, 5,   cl‑PARP↑, 2,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK4↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   P21↑, 3,   RB1↑, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   CSCs↓, 1,   EMT↓, 3,   ERK↓, 3,   ERK↑, 1,   p‑ERK↓, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   mTOR↓, 2,   NOTCH1↓, 4,   P70S6K↓, 1,   PI3K↓, 2,   RAS↓, 1,   STAT3↓, 3,   TAZ↓, 1,   TumCG↓, 2,   Wnt↓, 1,  

Migration ⓘ

AEG1↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   COL1↓, 1,   COL3A1↓, 1,   CXCL12↓, 1,   decorin↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   LEF1↓, 1,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 2,   MMPs↓, 2,   MOB1↓, 1,   N-cadherin↓, 1,   RAGE↓, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TSP-1↑, 1,   TumCMig↓, 3,   TumCP↓, 7,   Twist↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   EGFR↓, 2,   HIF-1↓, 1,   Hif1a↓, 2,   LOX1↓, 1,   NO↓, 1,   VEGF↓, 5,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   COX2↓, 7,   CRP↓, 1,   CXCL9↓, 2,   CXCR4↓, 2,   DCells↑, 1,   GNLY↓, 1,   HCAR2↑, 1,   IFN-γ↓, 14,   IKKα↓, 1,   IL1↓, 1,   IL1↑, 1,   IL10↓, 1,   IL10↑, 1,   IL17↑, 1,   IL1β↓, 4,   IL2↓, 1,   IL2↑, 1,   IL4↓, 1,   IL6↓, 4,   IL6↑, 1,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 5,   IP-10/CXCL-10↓, 1,   MCP1↓, 1,   MIP-1β↓, 1,   NF-kB↓, 6,   p‑NF-kB↑, 1,   PD-1↑, 1,   PD-L1↓, 2,   PD-L1↑, 1,   PGE2↓, 1,   PSA↓, 1,   RANTES↓, 1,   T-Cell↑, 1,   TLR4↓, 1,   TNF-α↓, 7,   TRIF↓, 1,  

Synaptic & Neurotransmission ⓘ

ADAM10?, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↓, 1,   ChemoSen↑, 4,   Dose↝, 2,   eff↑, 3,   MDR1↓, 1,   P450↓, 1,   RadioS↑, 2,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 2,   hTERT/TERT↓, 1,   IL6↓, 4,   IL6↑, 1,   PD-L1↓, 2,   PD-L1↑, 1,   PSA↓, 1,   RAGE↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   chemoP↑, 2,   hepatoP↑, 1,   OS↑, 2,   radioP↑, 1,   Risk↓, 1,   Weight↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,   IRF3↓, 1,  
Total Targets: 221

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 12,   Catalase↑, 5,   GPx↑, 4,   GSH↑, 8,   GSR↑, 2,   GSTs↑, 2,   HO-1↑, 6,   Keap1↓, 1,   lipid-P↓, 8,   MDA↓, 3,   MPO↓, 2,   NQO1↑, 1,   NRF2↑, 7,   ROS↓, 13,   SOD↑, 9,   TAC↑, 1,   TBARS↓, 1,   Thiols↑, 1,   Trx↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 6,   AMPK↑, 1,   PPARα↑, 2,   PPARγ↓, 1,   PPARγ↑, 1,   SIRT1↑, 2,   SREBP1↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Casp1↓, 1,   iNOS↓, 5,   iNOS↑, 1,   JNK↓, 2,   MAPK↓, 1,   necrosis↓, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 1,   HSP27↑, 1,   HSPs↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   p‑ERK↓, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   OCT4↓, 1,  

Migration ⓘ

AntiAg↑, 1,   AP-1↑, 1,   APP↓, 1,   CLDN1↑, 1,   E-sel↓, 1,   MMP-10↝, 1,   MUC1↑, 1,   Treg lymp↓, 1,   TXNIP↓, 1,   VCAM-1↓, 1,   ZO-1↑, 2,  

Angiogenesis & Vasculature ⓘ

ATF4↓, 1,   NO↓, 4,  

Barriers & Transport ⓘ

BBB↑, 1,   CLDN3↑, 1,   GLUT4↑, 1,   IBI↑, 1,   OATPs↓, 1,   OCLN↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD25+↓, 1,   CD4+↑, 1,   CD69↓, 1,   COX2↓, 5,   CRP↓, 1,   CTLA-4↓, 1,   CXCc↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 20,   IKKα↓, 2,   p‑IKKα↓, 1,   IL1↓, 1,   IL10↓, 1,   IL10↑, 4,   IL12↓, 2,   IL17↓, 4,   IL18↓, 1,   IL1β↓, 7,   IL2↓, 6,   IL4↓, 4,   IL6↓, 11,   IL8↓, 3,   Inflam↓, 15,   MCP1↓, 2,   MIP‑1α↓, 1,   MyD88↓, 1,   NF-kB↓, 11,   PGE2↓, 5,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 16,   TNF-α↑, 1,   TNF-β↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 1,   p‑tau↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 2,   BACE↓, 1,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 4,   eff↑, 1,   Half-Life↓, 1,   Half-Life↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 6,   AST↓, 5,   CRP↓, 1,   GutMicro↑, 2,   IL6↓, 11,  

Functional Outcomes ⓘ

AntiDiabetic↓, 1,   cardioP↑, 3,   cognitive↑, 1,   hepatoP↑, 7,   memory↑, 2,   neuroP↑, 3,   Pain↓, 1,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 3,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   Diar↓, 1,   IRF3↓, 1,  
Total Targets: 131

Scientific Paper Hit Count for: IFN-γ, Interferon-γ
5 Silymarin (Milk Thistle) silibinin
2 Astaxanthin
2 Luteolin
2 Magnetic Field Rotating
2 Magnetic Fields
2 Quercetin
2 Shikonin
2 Thymoquinone
1 alpha Linolenic acid
1 Betulinic acid
1 Bromelain
1 Boron
1 Butyrate
1 Capsaicin
1 Carvacrol
1 Chrysin
1 Curcumin
1 Electrical Pulses
1 Hydrogen Gas
1 Honokiol
1 Rapamycin
1 Lycopene
1 Piperine
1 Selenium
1 Sulforaphane (mainly Broccoli)
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:442  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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