CYP17A1 Cancer Research Results

CYP17A1, cytochrome P450 CYP17A1: Click to Expand ⟱
Source:
Type:
Cytochrome P450 17A1 is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10.
CYP17A1 is critically important in the treatment of castration resistant prostate cancer, for which the CYP17A1 inhibitor abiraterone has proven a highly effective drug. However, CYP17A1 inhibition is also being investigated for the treatment of breast cancer.

Elevated CYP17A1 levels have been observed in cancer, and its expression may correlate with tumor aggressiveness and patient survival.
Scientific Papers found: Click to Expand⟱
125- CUR,    Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway
- in-vitro, adrenal, H295R
CYP17A1↓,
CYP19↓,
*Nrf1↑, Curcumin has been shown to modulate molecular signaling pathways, such as the aryl hydrocarbon receptor, the induction of Nuclear factor erythroid 2-related factor 2 (Nrf2) or the inhibition of nuclear factor kappa-light-chain-enhancer of activated B
*NF-kB↓,
angioG↓, Curcumin can also inhibit angiogenesis and induce apoptosis on cancerous cells
Apoptosis↑,
AR↓, Curcumin has been shown to downregulate the androgen receptor in prostate cancer cells [11]
toxicity↓, Human trials using up to 8000 mg of curcumin found no evidence of toxicity [52].
BioAv↑, An important formulation has been the use of curcumin with piperine, which has been found to enhance the bioavailability as well as effects of curcumin


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CYP19↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   CYP17A1↓, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Nrf1↑, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: CYP17A1, cytochrome P450 CYP17A1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:449  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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