CYP11A1 Cancer Research Results

CYP11A1, CYP11A1: Click to Expand ⟱
Source:
Type:
CYP11A1: gene that encodes a cytochrome P450 enzyme that catalyzes the conversion of cholesterol to pregnenolone, a precursor of steroid hormones.

Elevated CYP11A1 levels have been observed in cancer, and its expression may correlate with tumor aggressiveness and patient survival.
Scientific Papers found: Click to Expand⟱
131- CUR,    Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer
- vitro+vivo, Pca, LNCaP - vitro+vivo, Pca, 22Rv1
AKR1C2↓, Curcumin upregulated AKR1C2 expression in LNCaP. by approximately 170‐fold at 50 μmol/L
CYP11A1↓, CYP11A1 and HSD3B2 were significantly decreased.
HSD3B↓,
DHT↓,
testos↓,
StAR↓,
SRD5A1↑,
AR↓, suggest that curcumin's natural bioactive compounds could have potent anticancer properties due to suppression of androgen production,
tumCV↓, cell viability of LNCaP decreased by 50% when 5 μmol/L of curcumin was added to the culture medium.
TumCG↓, 50 μmol/L of curcumin completely inhibit the growth of 22Rv1 cells.
Apoptosis↑, Induction of apoptosis after curcumin treatment

1496- SFN,  VitD3,    Association between histone deacetylase activity and vitamin D-dependent gene expressions in relation to sulforaphane in human colorectal cancer cells
- in-vitro, CRC, Caco-2
eff↑, data suggest that colon cancer cells respond to dietary components differently under different conditions.
VDR↑, in proliferating Caco-2 cells, D + SFN (P < 0.04) increased VDR expression and decreased CYP27B1
CYP11A1↓,
HDAC↓, Histone deacetylase (HDAC) inhibitor activity was assessed using HDAC I/II assay that measured global changes in acetylation status.


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   TumCG↓, 1,   VDR↑, 1,  

Migration ⓘ

AKR1C2↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CYP11A1↓, 2,   DHT↓, 1,   HSD3B↓, 1,   SRD5A1↑, 1,   StAR↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CYP11A1, CYP11A1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:454  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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