ChE Cancer Research Results

ChE, cholinesterase: Click to Expand ⟱
Source:
Type: enzyme
Cholinesterase is an enzyme that plays a crucial role in the nervous system by breaking down the neurotransmitter acetylcholine.
Some studies have found that cholinesterase inhibitors, which are compounds that block the activity of cholinesterase, may have anti-cancer effects.
Butyrylcholinesterase (BCHE) is a type of cholinesterase that has been found to be overexpressed in certain types of cancer, including breast, colon, and lung cancer.
Acetylcholinesterase (AChE) is another type of cholinesterase that has been found to be involved in the development and progression of certain types of cancer. Inhibitors of AChE have been shown to have anti-cancer effects in preclinical studies.
In general, alterations in cholinesterase activity, particularly AChE and BChE, can be associated with tumor behavior and prognosis in various cancer types. While high levels of cholinesterases may correlate with better outcomes in some cancers, the specific implications can vary depending on the cancer type and other molecular factors.
High AChE activity has been associated with better prognosis, while low activity may correlate with more aggressive disease.
Scientific Papers found: Click to Expand⟱
438- CUR,    Curcumin Reduces Colorectal Cancer Cell Proliferation and Migration and Slows In Vivo Growth of Liver Metastases in Rats
- vitro+vivo, CRC, CC531
TumCP↓, >30% 48hr
TumVol↓, 5.6 fold
Albumin↑,
ALP↑,
AST↑,
ALAT↑,
ChE↓,

7913- VT,    Review of the effects of vitexin in oxidative stress-related diseases
*antiOx↑, vitexin as an antioxidant against reactive oxygen species, lipid peroxidation, and other oxidative damages in a variety of oxidative stress‐related diseases,
*ROS↓, vitexin (10, 25, and 50 μM) dose‐dependently decreased ROS
*lipid-P↓,
*memory↑, including seizure, memory impairment, cerebral ischemia, neurotoxicity, myocardial and respiratory injury
*Stroke↓,
*cardioP↑, figure 2
*neuroP↑,
*Inflam↓,
*NRF2↑, Upregulation of antioxidant response genes (Nrf2, HO‐1, NQO‐1, and Grp78) Downregulated Gadd153
*HO-1↑,
*NQO1↑,
*GRP78/BiP↑,
*CHOP/DDIT3↓,
*BACE/β-secretase↓, (vitexin and quercetin 3‐O‐glucoside), isolated from Nelumbo nucifera embryos, showed a potent inhibitory activity against β‐site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) and Cholinesterase (ChE).
*ChE↓,
*AChE↓, Vitexin (100 µM) showed significant cholinesterase inhibitory effects for both acetylcholinesterase and butyrylcholinesterase activity
*BChE↓,
*GSH↑, vitexin could prevent the reduction of glutathione levels, the ferric‐reducing ability potential, and the free‐radical scavenger ability, inhibit the production of hyperalgesic cytokines, such as TNF‐α, IL‐1β, IL‐6, and IL‐33, and upreg
*TNF-α↓,
*IL1β↓,
*IL6↓,
*IL33↓,
*LDH↓, It also reduced LDH and CK activities and MDA level and increased SOD in the serum.
*MDA↓,
*SOD↑,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ChE↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↑, 1,   Albumin↑, 1,   ALP↑, 1,   AST↑, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDH↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   GRP78/BiP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL33↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,   ChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 27

Scientific Paper Hit Count for: ChE, cholinesterase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:470  State#:%  Dir#:1
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